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Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome

Spontaneous periodic hypothermia is a rare syndrome presenting with recurrent, centrally mediated hypothermia without an identifiable systemic cause or brain lesion. The case of an 88-year-old woman with recurrent hypothermia is reported. Despite intensive investigation, no other manifestations of h...

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Detalles Bibliográficos
Autores principales: Attout, Hassene, Amichi, Sofia, Belkheir, Youcef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727636/
https://www.ncbi.nlm.nih.gov/pubmed/33312996
http://dx.doi.org/10.12890/2020_001874
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author Attout, Hassene
Amichi, Sofia
Belkheir, Youcef
author_facet Attout, Hassene
Amichi, Sofia
Belkheir, Youcef
author_sort Attout, Hassene
collection PubMed
description Spontaneous periodic hypothermia is a rare syndrome presenting with recurrent, centrally mediated hypothermia without an identifiable systemic cause or brain lesion. The case of an 88-year-old woman with recurrent hypothermia is reported. Despite intensive investigation, no other manifestations of hypothalamic or autonomic dysfunction were found. No corpus callosum lesion was seen on MRI. The patient was successfully treated with clomipramine chlorhydrate. LEARNING POINTS: Periodic hypothermia in the elderly is a rare and possibly under-recognised syndrome. The causes of the syndrome remain unknown. Pharmacological trials have only been modestly successful.
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spelling pubmed-77276362020-12-11 Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome Attout, Hassene Amichi, Sofia Belkheir, Youcef Eur J Case Rep Intern Med Articles Spontaneous periodic hypothermia is a rare syndrome presenting with recurrent, centrally mediated hypothermia without an identifiable systemic cause or brain lesion. The case of an 88-year-old woman with recurrent hypothermia is reported. Despite intensive investigation, no other manifestations of hypothalamic or autonomic dysfunction were found. No corpus callosum lesion was seen on MRI. The patient was successfully treated with clomipramine chlorhydrate. LEARNING POINTS: Periodic hypothermia in the elderly is a rare and possibly under-recognised syndrome. The causes of the syndrome remain unknown. Pharmacological trials have only been modestly successful. SMC Media Srl 2020-09-28 /pmc/articles/PMC7727636/ /pubmed/33312996 http://dx.doi.org/10.12890/2020_001874 Text en © EFIM 2020 This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Articles
Attout, Hassene
Amichi, Sofia
Belkheir, Youcef
Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome
title Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome
title_full Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome
title_fullStr Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome
title_full_unstemmed Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome
title_short Spontaneous Periodic Hypothermia in the Elderly: A Rare or Under-Recognised Syndrome
title_sort spontaneous periodic hypothermia in the elderly: a rare or under-recognised syndrome
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727636/
https://www.ncbi.nlm.nih.gov/pubmed/33312996
http://dx.doi.org/10.12890/2020_001874
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