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hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery

Relevant, predictive normal, or disease model systems are of vital importance for drug development. The difference between nonhuman models and humans could contribute to clinical trial failures despite ideal nonhuman results. As a potential substitute for animal models, human induced pluripotent ste...

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Detalles Bibliográficos
Autores principales: Li, Junjun, Hua, Ying, Miyagawa, Shigeru, Zhang, Jingbo, Li, Lingjun, Liu, Li, Sawa, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727666/
https://www.ncbi.nlm.nih.gov/pubmed/33255277
http://dx.doi.org/10.3390/ijms21238893
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author Li, Junjun
Hua, Ying
Miyagawa, Shigeru
Zhang, Jingbo
Li, Lingjun
Liu, Li
Sawa, Yoshiki
author_facet Li, Junjun
Hua, Ying
Miyagawa, Shigeru
Zhang, Jingbo
Li, Lingjun
Liu, Li
Sawa, Yoshiki
author_sort Li, Junjun
collection PubMed
description Relevant, predictive normal, or disease model systems are of vital importance for drug development. The difference between nonhuman models and humans could contribute to clinical trial failures despite ideal nonhuman results. As a potential substitute for animal models, human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) provide a powerful tool for drug toxicity screening, modeling cardiovascular diseases, and drug discovery. Here, we review recent hiPSC-CM disease models and discuss the features of hiPSC-CMs, including subtype and maturation and the tissue engineering technologies for drug assessment. Updates from the international multisite collaborators/administrations for development of novel drug discovery paradigms are also summarized.
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spelling pubmed-77276662020-12-11 hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery Li, Junjun Hua, Ying Miyagawa, Shigeru Zhang, Jingbo Li, Lingjun Liu, Li Sawa, Yoshiki Int J Mol Sci Review Relevant, predictive normal, or disease model systems are of vital importance for drug development. The difference between nonhuman models and humans could contribute to clinical trial failures despite ideal nonhuman results. As a potential substitute for animal models, human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) provide a powerful tool for drug toxicity screening, modeling cardiovascular diseases, and drug discovery. Here, we review recent hiPSC-CM disease models and discuss the features of hiPSC-CMs, including subtype and maturation and the tissue engineering technologies for drug assessment. Updates from the international multisite collaborators/administrations for development of novel drug discovery paradigms are also summarized. MDPI 2020-11-24 /pmc/articles/PMC7727666/ /pubmed/33255277 http://dx.doi.org/10.3390/ijms21238893 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Junjun
Hua, Ying
Miyagawa, Shigeru
Zhang, Jingbo
Li, Lingjun
Liu, Li
Sawa, Yoshiki
hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery
title hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery
title_full hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery
title_fullStr hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery
title_full_unstemmed hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery
title_short hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery
title_sort hipsc-derived cardiac tissue for disease modeling and drug discovery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727666/
https://www.ncbi.nlm.nih.gov/pubmed/33255277
http://dx.doi.org/10.3390/ijms21238893
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