Small Molecule Soluble Epoxide Hydrolase Inhibitors in Multitarget and Combination Therapies for Inflammation and Cancer

The enzyme soluble epoxide hydrolase (sEH) plays a central role in metabolism of bioactive lipid signaling molecules. The substrate-specific hydrolase activity of sEH converts epoxyeicosatrienoic acids (EETs) to less bioactive dihydroxyeicosatrienoic acids. EETs exhibit anti-inflammatory, analgesic,...

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Detalles Bibliográficos
Autores principales: Das Mahapatra, Amarjyoti, Choubey, Rinku, Datta, Bhaskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727688/
https://www.ncbi.nlm.nih.gov/pubmed/33255197
http://dx.doi.org/10.3390/molecules25235488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727688/
https://www.ncbi.nlm.nih.gov/pubmed/33255197
http://dx.doi.org/10.3390/molecules25235488

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