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The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients

PURPOSE: Relaxin is a polypeptide hormone produced by the corpus luteum and the decidua in females and by the prostate in males. It has vasodilatory and antifibrotic effects. In the past, it has been reported that injection of relaxin hormone has caused a reduction in the intraocular pressure althou...

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Autores principales: Zloto, Ofira, Skaat, Alon, Fabian, Ido Didi, Rosner, Mordechai, Ziv, Hana, Leshno, Ari, Melamed, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728022/
https://www.ncbi.nlm.nih.gov/pubmed/32971620
http://dx.doi.org/10.4103/ijo.IJO_2008_19
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author Zloto, Ofira
Skaat, Alon
Fabian, Ido Didi
Rosner, Mordechai
Ziv, Hana
Leshno, Ari
Melamed, Shlomo
author_facet Zloto, Ofira
Skaat, Alon
Fabian, Ido Didi
Rosner, Mordechai
Ziv, Hana
Leshno, Ari
Melamed, Shlomo
author_sort Zloto, Ofira
collection PubMed
description PURPOSE: Relaxin is a polypeptide hormone produced by the corpus luteum and the decidua in females and by the prostate in males. It has vasodilatory and antifibrotic effects. In the past, it has been reported that injection of relaxin hormone has caused a reduction in the intraocular pressure although its mechanism has not yet been fully understood and the expression of relaxin receptors has not yet been evident in the human eye. Therefore, the purpose of this current study was to examine the presence of relaxin receptors in the human eye anterior segment. METHODS: This is an interventional non-randomized study. Patients with primary open-angle glaucoma who underwent trabeculectomy were recruited. During the surgery, a punch biopsy (including the cornea, sclera, trabecular meshwork, and Schlemm's canal) was taken and stained with hematoxylin-eosin, and immunohistochemistry staining for relaxin/insulin-like family peptide receptor 1 (RXFP1). RESULTS: A positive staining was noted for RXFP1 in the inner uveal, corneoscleral, and cribriform meshwork and Schlemm's canal's endothelium. Negative staining for RXFP1 was noted in the cornea and sclera. CONCLUSION: RXFP1 is present in the anterior segment drainage system of the human eye. Therefore, this receptor may have an active role in regulating the outflow facility and in the reduction of intraocular pressure.
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spelling pubmed-77280222020-12-11 The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients Zloto, Ofira Skaat, Alon Fabian, Ido Didi Rosner, Mordechai Ziv, Hana Leshno, Ari Melamed, Shlomo Indian J Ophthalmol Original Article PURPOSE: Relaxin is a polypeptide hormone produced by the corpus luteum and the decidua in females and by the prostate in males. It has vasodilatory and antifibrotic effects. In the past, it has been reported that injection of relaxin hormone has caused a reduction in the intraocular pressure although its mechanism has not yet been fully understood and the expression of relaxin receptors has not yet been evident in the human eye. Therefore, the purpose of this current study was to examine the presence of relaxin receptors in the human eye anterior segment. METHODS: This is an interventional non-randomized study. Patients with primary open-angle glaucoma who underwent trabeculectomy were recruited. During the surgery, a punch biopsy (including the cornea, sclera, trabecular meshwork, and Schlemm's canal) was taken and stained with hematoxylin-eosin, and immunohistochemistry staining for relaxin/insulin-like family peptide receptor 1 (RXFP1). RESULTS: A positive staining was noted for RXFP1 in the inner uveal, corneoscleral, and cribriform meshwork and Schlemm's canal's endothelium. Negative staining for RXFP1 was noted in the cornea and sclera. CONCLUSION: RXFP1 is present in the anterior segment drainage system of the human eye. Therefore, this receptor may have an active role in regulating the outflow facility and in the reduction of intraocular pressure. Wolters Kluwer - Medknow 2020-10 2020-09-23 /pmc/articles/PMC7728022/ /pubmed/32971620 http://dx.doi.org/10.4103/ijo.IJO_2008_19 Text en Copyright: © 2020 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Zloto, Ofira
Skaat, Alon
Fabian, Ido Didi
Rosner, Mordechai
Ziv, Hana
Leshno, Ari
Melamed, Shlomo
The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients
title The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients
title_full The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients
title_fullStr The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients
title_full_unstemmed The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients
title_short The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients
title_sort distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728022/
https://www.ncbi.nlm.nih.gov/pubmed/32971620
http://dx.doi.org/10.4103/ijo.IJO_2008_19
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