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MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is one of the most common conditions worldwide that targets the liver parenchyma. NAFLD represents an intrahepatic triglyceride accumulation in the absence of excessive alcohol consumption and other diseases that affect the liver parenchyma. The current “gol...

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Autores principales: Lăpădat, Alina Maria, Florescu, Lucian Mihai, Manea, Nicolae Cătălin, Gheonea, Dan Ionuţ, Pirici, Daniel, Tudoraşcu, Diana Rodica, Ene, Răzvan, Gheonea, Ioana Andreea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728118/
https://www.ncbi.nlm.nih.gov/pubmed/32747897
http://dx.doi.org/10.47162/RJME.61.1.08
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author Lăpădat, Alina Maria
Florescu, Lucian Mihai
Manea, Nicolae Cătălin
Gheonea, Dan Ionuţ
Pirici, Daniel
Tudoraşcu, Diana Rodica
Ene, Răzvan
Gheonea, Ioana Andreea
author_facet Lăpădat, Alina Maria
Florescu, Lucian Mihai
Manea, Nicolae Cătălin
Gheonea, Dan Ionuţ
Pirici, Daniel
Tudoraşcu, Diana Rodica
Ene, Răzvan
Gheonea, Ioana Andreea
author_sort Lăpădat, Alina Maria
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is one of the most common conditions worldwide that targets the liver parenchyma. NAFLD represents an intrahepatic triglyceride accumulation in the absence of excessive alcohol consumption and other diseases that affect the liver parenchyma. The current “gold standard” for evaluating the amount of intrahepatic fat is represented by liver biopsy, but many patients are reluctant and hardly accept undergoing this procedure due to its invasive nature. The current study addresses this aspect by evaluating the reliability of liver magnetic resonance spectroscopy (MRS) in diagnosing NAFLD, compared to the traditional invasive liver biopsy. The present study included a total of 38 patients based on several well-defined inclusion and exclusion criteria. We used the same NAFLD grading system for both liver MRS and liver biopsy: grade 0: <5% hepatocytes are affected; grade I: 5–33% hepatocytes are affected; grade II: 34–66% hepatocytes are affected; grade III: >66% hepatocytes are affected. Regarding the NAFLD grade, over three-quarters of patients were classified as grade I and grade II, with a strong predilection for men. The current results indicated a significant association between the NAFLD grade indicated by liver MRS and the NAFLD grade indicated by liver biopsy. At the end of our study, we recommend using liver MRS for evaluating and grading NAFLD in association with other parameters like serum triglycerides and body mass index grade as this protocol can enhance early detection and provide an accurate grading that will lead to a proper management of this disease.
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spelling pubmed-77281182020-12-18 MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease Lăpădat, Alina Maria Florescu, Lucian Mihai Manea, Nicolae Cătălin Gheonea, Dan Ionuţ Pirici, Daniel Tudoraşcu, Diana Rodica Ene, Răzvan Gheonea, Ioana Andreea Rom J Morphol Embryol Original Paper Non-alcoholic fatty liver disease (NAFLD) is one of the most common conditions worldwide that targets the liver parenchyma. NAFLD represents an intrahepatic triglyceride accumulation in the absence of excessive alcohol consumption and other diseases that affect the liver parenchyma. The current “gold standard” for evaluating the amount of intrahepatic fat is represented by liver biopsy, but many patients are reluctant and hardly accept undergoing this procedure due to its invasive nature. The current study addresses this aspect by evaluating the reliability of liver magnetic resonance spectroscopy (MRS) in diagnosing NAFLD, compared to the traditional invasive liver biopsy. The present study included a total of 38 patients based on several well-defined inclusion and exclusion criteria. We used the same NAFLD grading system for both liver MRS and liver biopsy: grade 0: <5% hepatocytes are affected; grade I: 5–33% hepatocytes are affected; grade II: 34–66% hepatocytes are affected; grade III: >66% hepatocytes are affected. Regarding the NAFLD grade, over three-quarters of patients were classified as grade I and grade II, with a strong predilection for men. The current results indicated a significant association between the NAFLD grade indicated by liver MRS and the NAFLD grade indicated by liver biopsy. At the end of our study, we recommend using liver MRS for evaluating and grading NAFLD in association with other parameters like serum triglycerides and body mass index grade as this protocol can enhance early detection and provide an accurate grading that will lead to a proper management of this disease. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2020-06-18 /pmc/articles/PMC7728118/ /pubmed/32747897 http://dx.doi.org/10.47162/RJME.61.1.08 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
Lăpădat, Alina Maria
Florescu, Lucian Mihai
Manea, Nicolae Cătălin
Gheonea, Dan Ionuţ
Pirici, Daniel
Tudoraşcu, Diana Rodica
Ene, Răzvan
Gheonea, Ioana Andreea
MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease
title MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease
title_full MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease
title_fullStr MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease
title_full_unstemmed MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease
title_short MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease
title_sort mr spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728118/
https://www.ncbi.nlm.nih.gov/pubmed/32747897
http://dx.doi.org/10.47162/RJME.61.1.08
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