Cargando…
Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma)
Phyllodes tumors of the breast are biphasic tumors consisting from an epithelial component and a mesenchymal component. Usually, the mesenchymal component of the tumor is the one who dictates the malignancy of the biphasic proliferation. Presence of the malignancy of the both, epithelial [under the...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728119/ https://www.ncbi.nlm.nih.gov/pubmed/32747903 http://dx.doi.org/10.47162/RJME.61.1.14 |
_version_ | 1783621204457816064 |
---|---|
author | Nistor-Ciurba, Codruţ-Cosmin Şomcutian, Oana Lisencu, Ioan Cosmin Ignat, Florin Laurenţiu Lazăr, Gabriel Lucian Eniu, Dan Tudor |
author_facet | Nistor-Ciurba, Codruţ-Cosmin Şomcutian, Oana Lisencu, Ioan Cosmin Ignat, Florin Laurenţiu Lazăr, Gabriel Lucian Eniu, Dan Tudor |
author_sort | Nistor-Ciurba, Codruţ-Cosmin |
collection | PubMed |
description | Phyllodes tumors of the breast are biphasic tumors consisting from an epithelial component and a mesenchymal component. Usually, the mesenchymal component of the tumor is the one who dictates the malignancy of the biphasic proliferation. Presence of the malignancy of the both, epithelial [under the form of invasive carcinoma or ductal carcinoma in situ (DCIS)] and mesenchymal components is very rare. Most of the data available from the literature refers to single case presentations. This paper presents the experience of Prof. Dr. Ion Chiricuţă Oncological Institute (IOCN), Cluj-Napoca, Romania, with the malignant phyllodes tumors with both epithelial and mesenchymal components showing malignancy. Over two decades (1999–2018), four cases of malignant phyllodes tumors with concomitant epithelial and mesenchymal malignancy were found and presented as a case series. Two out of four cases were malignant phyllodes tumors harboring invasive breast carcinomas (one case with associated DCIS and one case of pure invasive carcinoma) and two cases were malignant phyllodes tumors with the epithelial component showing DCIS. Average follow-up period was 67 months (from 39 to 132 months) with a disease-free survival of 58 months. |
format | Online Article Text |
id | pubmed-7728119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest |
record_format | MEDLINE/PubMed |
spelling | pubmed-77281192020-12-18 Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma) Nistor-Ciurba, Codruţ-Cosmin Şomcutian, Oana Lisencu, Ioan Cosmin Ignat, Florin Laurenţiu Lazăr, Gabriel Lucian Eniu, Dan Tudor Rom J Morphol Embryol Original Paper Phyllodes tumors of the breast are biphasic tumors consisting from an epithelial component and a mesenchymal component. Usually, the mesenchymal component of the tumor is the one who dictates the malignancy of the biphasic proliferation. Presence of the malignancy of the both, epithelial [under the form of invasive carcinoma or ductal carcinoma in situ (DCIS)] and mesenchymal components is very rare. Most of the data available from the literature refers to single case presentations. This paper presents the experience of Prof. Dr. Ion Chiricuţă Oncological Institute (IOCN), Cluj-Napoca, Romania, with the malignant phyllodes tumors with both epithelial and mesenchymal components showing malignancy. Over two decades (1999–2018), four cases of malignant phyllodes tumors with concomitant epithelial and mesenchymal malignancy were found and presented as a case series. Two out of four cases were malignant phyllodes tumors harboring invasive breast carcinomas (one case with associated DCIS and one case of pure invasive carcinoma) and two cases were malignant phyllodes tumors with the epithelial component showing DCIS. Average follow-up period was 67 months (from 39 to 132 months) with a disease-free survival of 58 months. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2020-06-02 /pmc/articles/PMC7728119/ /pubmed/32747903 http://dx.doi.org/10.47162/RJME.61.1.14 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. |
spellingShingle | Original Paper Nistor-Ciurba, Codruţ-Cosmin Şomcutian, Oana Lisencu, Ioan Cosmin Ignat, Florin Laurenţiu Lazăr, Gabriel Lucian Eniu, Dan Tudor Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma) |
title | Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma) |
title_full | Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma) |
title_fullStr | Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma) |
title_full_unstemmed | Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma) |
title_short | Malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma) |
title_sort | malignant phyllodes tumors of the breast associating malignancy of both mesenchymal and epithelial components (invasive or in situ ductal carcinoma) |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728119/ https://www.ncbi.nlm.nih.gov/pubmed/32747903 http://dx.doi.org/10.47162/RJME.61.1.14 |
work_keys_str_mv | AT nistorciurbacodrutcosmin malignantphyllodestumorsofthebreastassociatingmalignancyofbothmesenchymalandepithelialcomponentsinvasiveorinsituductalcarcinoma AT somcutianoana malignantphyllodestumorsofthebreastassociatingmalignancyofbothmesenchymalandepithelialcomponentsinvasiveorinsituductalcarcinoma AT lisencuioancosmin malignantphyllodestumorsofthebreastassociatingmalignancyofbothmesenchymalandepithelialcomponentsinvasiveorinsituductalcarcinoma AT ignatflorinlaurentiu malignantphyllodestumorsofthebreastassociatingmalignancyofbothmesenchymalandepithelialcomponentsinvasiveorinsituductalcarcinoma AT lazargabriellucian malignantphyllodestumorsofthebreastassociatingmalignancyofbothmesenchymalandepithelialcomponentsinvasiveorinsituductalcarcinoma AT eniudantudor malignantphyllodestumorsofthebreastassociatingmalignancyofbothmesenchymalandepithelialcomponentsinvasiveorinsituductalcarcinoma |