TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice

The development of HIV-1 vaccines is challenged by the lack of relevant models to accurately induce human B- and T-cell responses in lymphoid organs. In humanized mice reconstituted with human hematopoietic stem cells (hu-mice), human B cell-development and function are impaired and cells fail to ef...

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Detalles Bibliográficos
Autores principales: Godot, Véronique, Tcherakian, Colas, Gil, Laurine, Cervera-Marzal, Iñaki, Li, Guangming, Cheng, Liang, Ortonne, Nicolas, Lelièvre, Jean-Daniel, Pantaleo, Giuseppe, Fenwick, Craig, Centlivre, Mireille, Mouquet, Hugo, Cardinaud, Sylvain, Zurawski, Sandra M., Zurawski, Gerard, Milpied, Pierre, Su, Lishan, Lévy, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728200/
https://www.ncbi.nlm.nih.gov/pubmed/33253297
http://dx.doi.org/10.1371/journal.ppat.1009025

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