Vesicular trafficking permits evasion of cGAS/STING surveillance during initial human papillomavirus infection

Oncogenic human papillomaviruses (HPVs) replicate in differentiating epithelium, causing 5% of cancers worldwide. Like most other DNA viruses, HPV infection initiates after trafficking viral genome (vDNA) to host cell nuclei. Cells possess innate surveillance pathways to detect microbial components...

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Detalles Bibliográficos
Autores principales: Uhlorn, Brittany L., Jackson, Robert, Li, Shuaizhi, Bratton, Shauna M., Van Doorslaer, Koenraad, Campos, Samuel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728285/
https://www.ncbi.nlm.nih.gov/pubmed/33253291
http://dx.doi.org/10.1371/journal.ppat.1009028

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