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Cellulose Composites with Graphene for Tissue Engineering Applications

Tissue engineering is an interdisciplinary field that combines principles of engineering and life sciences to obtain biomaterials capable of maintaining, improving, or substituting the function of various tissues or even an entire organ. In virtue of its high availability, biocompatibility and versa...

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Autores principales: Oprea, Madalina, Voicu, Stefan Ioan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728350/
https://www.ncbi.nlm.nih.gov/pubmed/33255827
http://dx.doi.org/10.3390/ma13235347
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author Oprea, Madalina
Voicu, Stefan Ioan
author_facet Oprea, Madalina
Voicu, Stefan Ioan
author_sort Oprea, Madalina
collection PubMed
description Tissue engineering is an interdisciplinary field that combines principles of engineering and life sciences to obtain biomaterials capable of maintaining, improving, or substituting the function of various tissues or even an entire organ. In virtue of its high availability, biocompatibility and versatility, cellulose was considered a promising platform for such applications. The combination of cellulose with graphene or graphene derivatives leads to the obtainment of superior composites in terms of cellular attachment, growth and proliferation, integration into host tissue, and stem cell differentiation toward specific lineages. The current review provides an up-to-date summary of the status of the field of cellulose composites with graphene for tissue engineering applications. The preparation methods and the biological performance of cellulose paper, bacterial cellulose, and cellulose derivatives-based composites with graphene, graphene oxide and reduced graphene oxide were mainly discussed. The importance of the cellulose-based matrix and the contribution of graphene and graphene derivatives fillers as well as several key applications of these hybrid materials, particularly for the development of multifunctional scaffolds for cell culture, bone and neural tissue regeneration were also highlighted.
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spelling pubmed-77283502020-12-11 Cellulose Composites with Graphene for Tissue Engineering Applications Oprea, Madalina Voicu, Stefan Ioan Materials (Basel) Review Tissue engineering is an interdisciplinary field that combines principles of engineering and life sciences to obtain biomaterials capable of maintaining, improving, or substituting the function of various tissues or even an entire organ. In virtue of its high availability, biocompatibility and versatility, cellulose was considered a promising platform for such applications. The combination of cellulose with graphene or graphene derivatives leads to the obtainment of superior composites in terms of cellular attachment, growth and proliferation, integration into host tissue, and stem cell differentiation toward specific lineages. The current review provides an up-to-date summary of the status of the field of cellulose composites with graphene for tissue engineering applications. The preparation methods and the biological performance of cellulose paper, bacterial cellulose, and cellulose derivatives-based composites with graphene, graphene oxide and reduced graphene oxide were mainly discussed. The importance of the cellulose-based matrix and the contribution of graphene and graphene derivatives fillers as well as several key applications of these hybrid materials, particularly for the development of multifunctional scaffolds for cell culture, bone and neural tissue regeneration were also highlighted. MDPI 2020-11-25 /pmc/articles/PMC7728350/ /pubmed/33255827 http://dx.doi.org/10.3390/ma13235347 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oprea, Madalina
Voicu, Stefan Ioan
Cellulose Composites with Graphene for Tissue Engineering Applications
title Cellulose Composites with Graphene for Tissue Engineering Applications
title_full Cellulose Composites with Graphene for Tissue Engineering Applications
title_fullStr Cellulose Composites with Graphene for Tissue Engineering Applications
title_full_unstemmed Cellulose Composites with Graphene for Tissue Engineering Applications
title_short Cellulose Composites with Graphene for Tissue Engineering Applications
title_sort cellulose composites with graphene for tissue engineering applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728350/
https://www.ncbi.nlm.nih.gov/pubmed/33255827
http://dx.doi.org/10.3390/ma13235347
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