EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma

Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and contributes to the block of differentiation. Epigenetic mechanisms leading to its suppression are unknown and could pave the way toward novel therapeutic modalities. We demonstrate that EHMT2 suppresses canonical Wnt signaling b...

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Detalles Bibliográficos
Autores principales: Pal, Ananya, Leung, Jia Yu, Ang, Gareth Chin Khye, Rao, Vinay Kumar, Pignata, Luca, Lim, Huey Jin, Hebrard, Maxime, Chang, Kenneth TE, Lee, Victor KM, Guccione, Ernesto, Taneja, Reshma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728445/
https://www.ncbi.nlm.nih.gov/pubmed/33252038
http://dx.doi.org/10.7554/eLife.57683

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