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Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors: Preliminary Study
BACKGROUND AND PURPOSE: Recent attempts to utilize diffusion tensor imaging (DTI) to identify the extent of microinfiltration of a tumor in the brain have been successful. It was therefore speculated that this technique could also be useful in the spinal cord. The aim of this study was to differenti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728647/ https://www.ncbi.nlm.nih.gov/pubmed/31754759 http://dx.doi.org/10.1007/s00062-019-00851-8 |
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author | Maj, Edyta Szemplińska, Barbara Szeszkowski, Wojciech Prokopienko, Marek Cieszanowski, Andrzej Marchel, Andrzej Rowiński, Olgierd |
author_facet | Maj, Edyta Szemplińska, Barbara Szeszkowski, Wojciech Prokopienko, Marek Cieszanowski, Andrzej Marchel, Andrzej Rowiński, Olgierd |
author_sort | Maj, Edyta |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Recent attempts to utilize diffusion tensor imaging (DTI) to identify the extent of microinfiltration of a tumor in the brain have been successful. It was therefore speculated that this technique could also be useful in the spinal cord. The aim of this study was to differentiate between infiltrating and noninfiltrating intramedullary spinal tumors using DTI-derived metrics. MATERIAL AND METHODS: The study group consisted of 6 patients with infiltrating and 12 with noninfiltrating spinal cord tumors. Conventional magnetic resonance imaging (MRI) with gadolinium administration was performed followed by DTI. Fractional anisotropy (FA), diffusivity (TRACE) and apparent diffusion coefficient (ADC) were measured in the enhancing tumor mass, peritumoral margins, peritumoral edema and normal appearing spinal cord. The results were compared using non-parametric Mann–Whitney U test with statistical significance p < 0.05. RESULTS: In peritumoral margins the FA values were significantly higher in the noninfiltrating compared to the infiltrating tumors (p < 0.007), whereas TRACE values were significantly lower (p < 0.017). The results were similar in peritumoral edema. The FA values in the tumor mass showed no significant differences between the two groups while TRACE showed a statistically significant difference (p < 0.003). There was no statistical difference in any parameters in normal appearing spinal cord. CONCLUSION: Quantitative analysis of DTI parameters of spinal cord tissue surroundings spinal masses can be useful for differentiation between infiltrating and non-infiltrating intramedullary spinal tumors. |
format | Online Article Text |
id | pubmed-7728647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-77286472020-12-17 Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors: Preliminary Study Maj, Edyta Szemplińska, Barbara Szeszkowski, Wojciech Prokopienko, Marek Cieszanowski, Andrzej Marchel, Andrzej Rowiński, Olgierd Clin Neuroradiol Original Article BACKGROUND AND PURPOSE: Recent attempts to utilize diffusion tensor imaging (DTI) to identify the extent of microinfiltration of a tumor in the brain have been successful. It was therefore speculated that this technique could also be useful in the spinal cord. The aim of this study was to differentiate between infiltrating and noninfiltrating intramedullary spinal tumors using DTI-derived metrics. MATERIAL AND METHODS: The study group consisted of 6 patients with infiltrating and 12 with noninfiltrating spinal cord tumors. Conventional magnetic resonance imaging (MRI) with gadolinium administration was performed followed by DTI. Fractional anisotropy (FA), diffusivity (TRACE) and apparent diffusion coefficient (ADC) were measured in the enhancing tumor mass, peritumoral margins, peritumoral edema and normal appearing spinal cord. The results were compared using non-parametric Mann–Whitney U test with statistical significance p < 0.05. RESULTS: In peritumoral margins the FA values were significantly higher in the noninfiltrating compared to the infiltrating tumors (p < 0.007), whereas TRACE values were significantly lower (p < 0.017). The results were similar in peritumoral edema. The FA values in the tumor mass showed no significant differences between the two groups while TRACE showed a statistically significant difference (p < 0.003). There was no statistical difference in any parameters in normal appearing spinal cord. CONCLUSION: Quantitative analysis of DTI parameters of spinal cord tissue surroundings spinal masses can be useful for differentiation between infiltrating and non-infiltrating intramedullary spinal tumors. Springer Berlin Heidelberg 2019-11-21 2020 /pmc/articles/PMC7728647/ /pubmed/31754759 http://dx.doi.org/10.1007/s00062-019-00851-8 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Maj, Edyta Szemplińska, Barbara Szeszkowski, Wojciech Prokopienko, Marek Cieszanowski, Andrzej Marchel, Andrzej Rowiński, Olgierd Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors: Preliminary Study |
title | Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors: Preliminary Study |
title_full | Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors: Preliminary Study |
title_fullStr | Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors: Preliminary Study |
title_full_unstemmed | Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors: Preliminary Study |
title_short | Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors: Preliminary Study |
title_sort | role of diffusion tensor imaging parameters in the characterization and differentiation of infiltrating and non-infiltrating spinal cord tumors: preliminary study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728647/ https://www.ncbi.nlm.nih.gov/pubmed/31754759 http://dx.doi.org/10.1007/s00062-019-00851-8 |
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