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Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis

Biocompatibility of hemodialysis (HD) systems have been considerably improved. However, mortality and morbidity rates of patients have remained high, raising questions regarding the biocompatibility of current systems. In the present study, 70 patients on regular HD (51 males; mean age, 63 years; me...

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Autores principales: Fukushi, Taro, Yamamoto, Tae, Yoshida, Mai, Fujikura, Emi, Miyazaki, Mariko, Nakayama, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728788/
https://www.ncbi.nlm.nih.gov/pubmed/33303892
http://dx.doi.org/10.1038/s41598-020-78742-z
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author Fukushi, Taro
Yamamoto, Tae
Yoshida, Mai
Fujikura, Emi
Miyazaki, Mariko
Nakayama, Masaaki
author_facet Fukushi, Taro
Yamamoto, Tae
Yoshida, Mai
Fujikura, Emi
Miyazaki, Mariko
Nakayama, Masaaki
author_sort Fukushi, Taro
collection PubMed
description Biocompatibility of hemodialysis (HD) systems have been considerably improved. However, mortality and morbidity rates of patients have remained high, raising questions regarding the biocompatibility of current systems. In the present study, 70 patients on regular HD (51 males; mean age, 63 years; median duration of HD, 18 months) with high-performance membrane (polysulfone, 77%; polymethylmethacrylate, 23%) at Tohoku University Hospital were examined. Blood samples before and after HD, were subjected to measure apoptosis cells of white blood cells, plasma levels of the following molecules: myeloperoxidase (MPO), pentraxin 3 (PTX3), angiogenin, complements, and 17 cytokines. The main findings were as follows: significant decreases in leukocyte counts by dialysis, significant increases in apoptosis-positive leukocytes by dialysis (neutrophils and monocytes), and significant decrease in plasma angiogenin accompanying increase in plasma MPO and PTX3 levels, with no or only marginal changes in plasma pro-inflammatory cytokine levels and complement products by dialysis. The findings underlined the unsolved issue of bio-incompatibility of HD systems, and suggest the possible pathology of neutrophil apoptosis accompanying MPO release for the development of microinflammation in patients on HD.
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spelling pubmed-77287882020-12-14 Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis Fukushi, Taro Yamamoto, Tae Yoshida, Mai Fujikura, Emi Miyazaki, Mariko Nakayama, Masaaki Sci Rep Article Biocompatibility of hemodialysis (HD) systems have been considerably improved. However, mortality and morbidity rates of patients have remained high, raising questions regarding the biocompatibility of current systems. In the present study, 70 patients on regular HD (51 males; mean age, 63 years; median duration of HD, 18 months) with high-performance membrane (polysulfone, 77%; polymethylmethacrylate, 23%) at Tohoku University Hospital were examined. Blood samples before and after HD, were subjected to measure apoptosis cells of white blood cells, plasma levels of the following molecules: myeloperoxidase (MPO), pentraxin 3 (PTX3), angiogenin, complements, and 17 cytokines. The main findings were as follows: significant decreases in leukocyte counts by dialysis, significant increases in apoptosis-positive leukocytes by dialysis (neutrophils and monocytes), and significant decrease in plasma angiogenin accompanying increase in plasma MPO and PTX3 levels, with no or only marginal changes in plasma pro-inflammatory cytokine levels and complement products by dialysis. The findings underlined the unsolved issue of bio-incompatibility of HD systems, and suggest the possible pathology of neutrophil apoptosis accompanying MPO release for the development of microinflammation in patients on HD. Nature Publishing Group UK 2020-12-10 /pmc/articles/PMC7728788/ /pubmed/33303892 http://dx.doi.org/10.1038/s41598-020-78742-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fukushi, Taro
Yamamoto, Tae
Yoshida, Mai
Fujikura, Emi
Miyazaki, Mariko
Nakayama, Masaaki
Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_full Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_fullStr Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_full_unstemmed Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_short Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_sort enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728788/
https://www.ncbi.nlm.nih.gov/pubmed/33303892
http://dx.doi.org/10.1038/s41598-020-78742-z
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