Case Report: Unmasked Inherited Dysfibrinogenemia After Everolimus Therapy

A previously hemostatically asymptomatic patient with common variable hypogammaglobulinemia was given everolimus to prevent growth of her liver. Within several months, the patient developed a severe bleeding disorder. The bleeding was due to fibrin polymerization defect that upon sequencing was show...

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Detalles Bibliográficos
Autores principales: Merkulova, Alona A., Mitchell, Steven C., Merkulov, Sergei, Wolberg, Alisa S., Neerman-Arbez, Marguerite, Schmaier, Alvin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729062/
https://www.ncbi.nlm.nih.gov/pubmed/33330551
http://dx.doi.org/10.3389/fmed.2020.591546
Descripción
Sumario:A previously hemostatically asymptomatic patient with common variable hypogammaglobulinemia was given everolimus to prevent growth of her liver. Within several months, the patient developed a severe bleeding disorder. The bleeding was due to fibrin polymerization defect that upon sequencing was shown to be dysfibrinogenemia Krakow III. Elimination of the mTor inhibitor ameliorated the clinical bleeding state.

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