Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia

BACKGROUND: Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. CASE REPORT: This report presents the r...

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Autores principales: Vaira, L A, Hopkins, C, Sandison, A, Manca, A, Machouchas, N, Turilli, D, Lechien, J R, Barillari, M R, Salzano, G, Cossu, A, Saussez, S, De Riu, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Clinical Records
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729153/
https://www.ncbi.nlm.nih.gov/pubmed/33190655
http://dx.doi.org/10.1017/S0022215120002455
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author Vaira, L A
Hopkins, C
Sandison, A
Manca, A
Machouchas, N
Turilli, D
Lechien, J R
Barillari, M R
Salzano, G
Cossu, A
Saussez, S
De Riu, G
author_facet Vaira, L A
Hopkins, C
Sandison, A
Manca, A
Machouchas, N
Turilli, D
Lechien, J R
Barillari, M R
Salzano, G
Cossu, A
Saussez, S
De Riu, G
author_sort Vaira, L A
collection PubMed
description BACKGROUND: Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. CASE REPORT: This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2. CONCLUSION: The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.
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spelling pubmed-77291532020-12-11 Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia Vaira, L A Hopkins, C Sandison, A Manca, A Machouchas, N Turilli, D Lechien, J R Barillari, M R Salzano, G Cossu, A Saussez, S De Riu, G J Laryngol Otol Clinical Records BACKGROUND: Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. CASE REPORT: This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2. CONCLUSION: The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium. Cambridge University Press 2020-11-16 /pmc/articles/PMC7729153/ /pubmed/33190655 http://dx.doi.org/10.1017/S0022215120002455 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Records
Vaira, L A
Hopkins, C
Sandison, A
Manca, A
Machouchas, N
Turilli, D
Lechien, J R
Barillari, M R
Salzano, G
Cossu, A
Saussez, S
De Riu, G
Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia
title Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia
title_full Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia
title_fullStr Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia
title_full_unstemmed Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia
title_short Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia
title_sort olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia
topic Clinical Records
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729153/
https://www.ncbi.nlm.nih.gov/pubmed/33190655
http://dx.doi.org/10.1017/S0022215120002455
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