Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review

Isoniazid (INH) is a first-line tuberculosis (TB) drug and is currently recommended as part of active and latent TB treatment in all ages. INH adverse reactions range from mild hepatitis to severe neurological symptoms and psychosis. Since its introduction in the 1950s, many case reports have explor...

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Autores principales: Alfawaz, Saleh, Alattas, Nadia, Alhammadi, Moza, Waqar, Saadia, Al Alola, Sulaiman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729223/
https://www.ncbi.nlm.nih.gov/pubmed/33319019
http://dx.doi.org/10.1016/j.ijpam.2020.03.012
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author Alfawaz, Saleh
Alattas, Nadia
Alhammadi, Moza
Waqar, Saadia
Al Alola, Sulaiman
author_facet Alfawaz, Saleh
Alattas, Nadia
Alhammadi, Moza
Waqar, Saadia
Al Alola, Sulaiman
author_sort Alfawaz, Saleh
collection PubMed
description Isoniazid (INH) is a first-line tuberculosis (TB) drug and is currently recommended as part of active and latent TB treatment in all ages. INH adverse reactions range from mild hepatitis to severe neurological symptoms and psychosis. Since its introduction in the 1950s, many case reports have explored INH-induced psychosis. We describe a 12-year-old girl with acute onset hallucinations and delusions as a rare complication of INH and review previous case reports and identified risk factors. Pediatricians need to be aware of this less common side effect as they work through a differential of acute psychosis in children.
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spelling pubmed-77292232020-12-13 Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review Alfawaz, Saleh Alattas, Nadia Alhammadi, Moza Waqar, Saadia Al Alola, Sulaiman Int J Pediatr Adolesc Med Article Isoniazid (INH) is a first-line tuberculosis (TB) drug and is currently recommended as part of active and latent TB treatment in all ages. INH adverse reactions range from mild hepatitis to severe neurological symptoms and psychosis. Since its introduction in the 1950s, many case reports have explored INH-induced psychosis. We describe a 12-year-old girl with acute onset hallucinations and delusions as a rare complication of INH and review previous case reports and identified risk factors. Pediatricians need to be aware of this less common side effect as they work through a differential of acute psychosis in children. King Faisal Specialist Hospital and Research Centre 2020-12 2020-04-05 /pmc/articles/PMC7729223/ /pubmed/33319019 http://dx.doi.org/10.1016/j.ijpam.2020.03.012 Text en © 2020 Publishing services provided by Elsevier B.V. on behalf of King Faisal Specialist Hospital & Research Centre (General Organization), Saudi Arabia. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Alfawaz, Saleh
Alattas, Nadia
Alhammadi, Moza
Waqar, Saadia
Al Alola, Sulaiman
Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review
title Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review
title_full Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review
title_fullStr Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review
title_full_unstemmed Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review
title_short Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review
title_sort acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: a case report and literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729223/
https://www.ncbi.nlm.nih.gov/pubmed/33319019
http://dx.doi.org/10.1016/j.ijpam.2020.03.012
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