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Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

BACKGROUND: Mutations that inactivate MarR reduce susceptibility to ciprofloxacin and competitive growth fitness in Escherichia coli. Both phenotypes are caused by overexpression of the MarA regulon, which includes the AcrAB-TolC drug efflux pump. OBJECTIVES: We asked whether compensatory evolution...

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Detalles Bibliográficos
Autores principales:	Praski Alzrigat, Lisa, Huseby, Douglas L, Brandis, Gerrit, Hughes, Diarmaid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729382/ https://www.ncbi.nlm.nih.gov/pubmed/33089314 http://dx.doi.org/10.1093/jac/dkaa417

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