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Pharmacokinetic and pharmacodynamic analysis of baloxavir marboxil, a novel cap-dependent endonuclease inhibitor, in a murine model of influenza virus infection

BACKGROUND: Baloxavir acid, the active form of the orally available prodrug baloxavir marboxil, is a novel cap-dependent endonuclease inhibitor of influenza virus. Baloxavir marboxil has been shown to rapidly reduce virus titres compared with oseltamivir in clinical studies. OBJECTIVES: We investiga...

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Detalles Bibliográficos
Autores principales:	Ando, Yoshinori, Noshi, Takeshi, Sato, Kenji, Ishibashi, Toru, Yoshida, Yuki, Hasegawa, Takahiro, Onishi, Motoyasu, Kitano, Mitsutaka, Oka, Ryoko, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729387/ https://www.ncbi.nlm.nih.gov/pubmed/33035324 http://dx.doi.org/10.1093/jac/dkaa393

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