Cargando…

Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction

Sepsis aggregates undesirable immune response causing depression of ventricular myocardium and diastolic dysfunction. This present study examined the effect of a plant-derived flavone tangeretin (TG) on autophagy and reduction in myocardial dysfunction. The sepsis was induced by cecum ligation and p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shiroorkar, Predeepkumar Narayanappa, Afzal, Obaid, Kazmi, Imran, Al-Abbasi, Fahad A., Altamimi, Abdulmalik Saleh Alfawaz, Gubbiyappa, Kumar Shiva, Sreeharsha, Nagaraja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729459/ https://www.ncbi.nlm.nih.gov/pubmed/33260422 http://dx.doi.org/10.3390/molecules25235622

Ejemplares similares

Therapeutic effects of Crataegus monogyna inhibitors against breast cancer
por: Basavarajappa, Girish Meravanige, et al.
Publicado: (2023)

Topical Probiotics: More Than a Skin Deep
por: Habeebuddin, Mohammed, et al.
Publicado: (2022)

mTOR as a Potential Target for the Treatment of Microbial Infections, Inflammatory Bowel Diseases, and Colorectal Cancer
por: Afzal, Obaid, et al.
Publicado: (2022)

Nanomaterials in Dentistry: Current Applications and Future Scope
por: Sreenivasalu, Pavan Kumar Pavagada, et al.
Publicado: (2022)

Green Synthesis and Characterization of Silver Nanoparticles of Psidium guajava Leaf Extract and Evaluation for Its Antidiabetic Activity
por: Nagaraja, Sreeharsha, et al.
Publicado: (2022)

Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing
por: Monirul Islam, Mohammed, et al.
Publicado: (2022)

A spotlight on application of microwave-assisted modifications of plant derived polymers in designing novel drug delivery systems
por: Basavarajappa, Girish Meravanige, et al.
Publicado: (2023)

Cationic Solid Lipid Nanoparticles of Resveratrol for Hepatocellular Carcinoma Treatment: Systematic Optimization, in vitro Characterization and Preclinical Investigation
por: Rahman, Mahfoozur, et al.
Publicado: (2020)

Anticancer Effect of Rosiglitazone, a PPAR-γ Agonist against Diethylnitrosamine-Induced Lung Carcinogenesis
por: Wu, Yanqiao, et al.
Publicado: (2020)

Retraction of “Anticancer Effect of Rosiglitazone, a PPAR-γ Agonist against Diethylnitrosamine-Induced Lung Carcinogenesis”
por: Wu, Yanqiao, et al.
Publicado: (2021)

The Race to Replace PDE5i: Recent Advances and Interventions to Treat or Manage Erectile Dysfunction: Evidence from Patent Landscape (2016–2021)
por: Islam, Mohammed Monirul, et al.
Publicado: (2022)

Improved Subcutaneous Delivery of Ketoconazole Using EpiDerm and HSPiP Software-Based Simulations as Assessed by Cell Viability, Cellular Uptake, Permeation, and Hemolysis In Vitro Studies
por: Hussain, Afzal, et al.
Publicado: (2022)

Impact of Composition and Morphology of Ketoconazole-Loaded Solid Lipid Nanoparticles on Intestinal Permeation and Gastroplus-Based Prediction Studies
por: Aljurbui, Shaya Jubran, et al.
Publicado: (2022)

Preferential Solvation Study of Rosuvastatin in the {PEG400 (1) + Water (2)} Cosolvent Mixture and GastroPlus Software-Based In Vivo Predictions
por: Hussain, Afzal, et al.
Publicado: (2023)

Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase
por: Afzal, Obaid, et al.
Publicado: (2021)

Superficial Dermatophytosis across the World’s Populations: Potential Benefits from Nanocarrier-Based Therapies and Rising Challenges
por: Keshwania, Puja, et al.
Publicado: (2023)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro, in vivo evaluation, and dermatokinetic studies
por: Chen, Lihua, et al.
Publicado: (2021)

Gut Microbiota Disruption in COVID-19 or Post-COVID Illness Association with severity biomarkers: A Possible Role of Pre / Pro-biotics in manipulating microflora
por: Alharbi, Khalid Saad, et al.
Publicado: (2022)

A kNGR Peptide-Tethered Lipid–Polymer Hybrid Nanocarrier-Based Synergistic Approach for Effective Tumor Therapy: Development, Characterization, Ex-Vivo, and In-Vivo Assessment
por: Gupta, Madhu, et al.
Publicado: (2022)

Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma
por: Wang, Bin, et al.
Publicado: (2021)

Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
por: AlGhamdi, Shareefa A., et al.
Publicado: (2023)

Mechanistic of Vesicular Ethosomes and Elastic Liposomes on Permeation Profiles of Acyclovir across Artificial Membrane, Human Cultured EpiDerm, and Rat Skin: In Vitro-Ex Vivo Study
por: Hussain, Afzal, et al.
Publicado: (2023)

Design, Synthesis, ADME, and Anticancer Studies of Newer N-Aryl-5-(3,4,5-Trifluorophenyl)-1,3,4-Oxadiazol-2-Amines: An Insight into Experimental and Theoretical Investigations
por: Agarwal, Mohit, et al.
Publicado: (2023)

Thymoquinone Induced Leishmanicidal Effect via Programmed Cell Death in Leishmania donovani
por: Islamuddin, Mohammad, et al.
Publicado: (2022)

Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2022)

Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin
por: de Luna, Francisco Canindé Ferreira, et al.
Publicado: (2023)

Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma
por: Lu, Jianjun, et al.
Publicado: (2015)

Inhibition of Chikungunya Virus Infection by 4-Hydroxy-1-Methyl-3-(3-morpholinopropanoyl)quinoline-2(1H)-one (QVIR) Targeting nsP2 and E2 Proteins
por: Islamuddin, Mohammad, et al.
Publicado: (2021)

Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats
por: Han, Wen, et al.
Publicado: (2018)

Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ-Induced Kindled Epilepsy in Rats: In Vivo and In Silico
por: Alam, Md. Niyaz, et al.
Publicado: (2023)

Microencapsulation of Tangeretin in a Citrus Pectin Mixture Matrix
por: Sun, Xiuxiu, et al.
Publicado: (2020)

Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat
por: Hung, Wei-Lun, et al.
Publicado: (2017)

Role of PTEN, PI3K, and mTOR in Triple-Negative Breast Cancer
por: Prvanović, Mirjana, et al.
Publicado: (2021)

Targeting mTOR Pathway in PTEN Deleted Newly Isolated Chordoma Cell Line
por: Pagani, Francesca, et al.
Publicado: (2023)

Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway
por: Li, Pingping, et al.
Publicado: (2020)

Butin Mitigates Memory Impairment in Streptozotocin-Induced Diabetic Rats by Inhibiting Oxidative Stress and Inflammatory Responses
por: Omer, Asma B., et al.
Publicado: (2022)

The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
por: Nguyen, Lena H., et al.
Publicado: (2023)

Molecular mechanisms of mTOR regulation by stress
por: Heberle, Alexander Martin, et al.
Publicado: (2014)

Effect of mTOR Inhibitors in Nude Mice with Endometrial Carcinoma and Variable PTEN Expression Status
por: Fong, Pedro, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gjlaoblos922lats3jvfop463t