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Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity
Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the central or peripheral regulation of energy balance. These mutations are effective in causing the early onset of severe obesity and insatiable hunger (hyperphagia), suggesting that the genetic component ca...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729759/ https://www.ncbi.nlm.nih.gov/pubmed/33261141 http://dx.doi.org/10.3390/ijms21239035 |
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author | Chiurazzi, Martina Cozzolino, Mauro Orsini, Roberta Clara Di Maro, Martina Di Minno, Matteo Nicola Dario Colantuoni, Antonio |
author_facet | Chiurazzi, Martina Cozzolino, Mauro Orsini, Roberta Clara Di Maro, Martina Di Minno, Matteo Nicola Dario Colantuoni, Antonio |
author_sort | Chiurazzi, Martina |
collection | PubMed |
description | Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the central or peripheral regulation of energy balance. These mutations are effective in causing the early onset of severe obesity and insatiable hunger (hyperphagia), suggesting that the genetic component can contribute to 40–70% of obesity. However, genes’ roles in the processes leading to obesity are still unclear. This review is aimed to summarize the current knowledge of the genetic causes of obesity, especially monogenic obesity, describing the role of epigenetic mechanisms in obesity and metabolic diseases. A comprehensive understanding of the underlying genetic and epigenetic mechanisms, with the metabolic processes they control, will permit adequate management and prevention of obesity. |
format | Online Article Text |
id | pubmed-7729759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77297592020-12-12 Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity Chiurazzi, Martina Cozzolino, Mauro Orsini, Roberta Clara Di Maro, Martina Di Minno, Matteo Nicola Dario Colantuoni, Antonio Int J Mol Sci Review Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the central or peripheral regulation of energy balance. These mutations are effective in causing the early onset of severe obesity and insatiable hunger (hyperphagia), suggesting that the genetic component can contribute to 40–70% of obesity. However, genes’ roles in the processes leading to obesity are still unclear. This review is aimed to summarize the current knowledge of the genetic causes of obesity, especially monogenic obesity, describing the role of epigenetic mechanisms in obesity and metabolic diseases. A comprehensive understanding of the underlying genetic and epigenetic mechanisms, with the metabolic processes they control, will permit adequate management and prevention of obesity. MDPI 2020-11-27 /pmc/articles/PMC7729759/ /pubmed/33261141 http://dx.doi.org/10.3390/ijms21239035 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chiurazzi, Martina Cozzolino, Mauro Orsini, Roberta Clara Di Maro, Martina Di Minno, Matteo Nicola Dario Colantuoni, Antonio Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity |
title | Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity |
title_full | Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity |
title_fullStr | Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity |
title_full_unstemmed | Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity |
title_short | Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity |
title_sort | impact of genetic variations and epigenetic mechanisms on the risk of obesity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729759/ https://www.ncbi.nlm.nih.gov/pubmed/33261141 http://dx.doi.org/10.3390/ijms21239035 |
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