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Is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters?
Iodine, a key constituent of thyroid hormones, plays an indirect role in prenatal and postnatal growth. This study aimed to investigate whether breast milk iodine concentration (BMIC) is associated with growth‐ and obesity‐related hormones and subsequently the infants' anthropometric measures....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729768/ https://www.ncbi.nlm.nih.gov/pubmed/32990418 http://dx.doi.org/10.1111/mcn.13078 |
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author | Nazeri, Pantea Tahmasebinejad, Zhale Hedayati, Mehdi Mirmiran, Parvin Azizi, Fereidoun |
author_facet | Nazeri, Pantea Tahmasebinejad, Zhale Hedayati, Mehdi Mirmiran, Parvin Azizi, Fereidoun |
author_sort | Nazeri, Pantea |
collection | PubMed |
description | Iodine, a key constituent of thyroid hormones, plays an indirect role in prenatal and postnatal growth. This study aimed to investigate whether breast milk iodine concentration (BMIC) is associated with growth‐ and obesity‐related hormones and subsequently the infants' anthropometric measures. In present study conducted in Tehran (Iran), 94 lactating mothers and healthy infants who were exclusively breastfed were included. Concentrations of iodine, insulin‐like growth factor‐1 (IGF‐1), adiponectin (AD) and leptin (LP) were measured in breast milk samples collected during 3‐ to 5‐day postpartum. Anthropometric measures of infants were assessed at 6 months of life, and age‐ and sex‐specific z‐score values were calculated using the World Health Organization growth standards. The median (interquartile range) iodine, IGF‐1, AD and LP concentrations were 232.5 (157.5–296.0) μg L(−1), 15.7 (11.9–21.1) ng ml(−1), 13.2 (5.1–29.8) mg L(−1) and 1.16 (0.86–1.70) ng ml(−1) in breast milk, respectively. No significant correlations were found between BMIC and IGF‐1, AD and LP concentrations during the first few days postpartum. In adjusted regression model, BMIC was positively associated with weight‐for‐length z score of infants. In the presence of IGF‐1, AD or LP, the coefficients of BMIC for weight‐for‐length z score of infants were β = .003 (P = .021), β = .002 (P = .028) or β = .003 (P = .013), respectively. No other anthropometric measurements were associated with iodine or growth‐ and obesity‐related hormones in breast milk. Our findings indicate that BMIC is a potential contributor to infants' growth status, independent of IGF‐1, AD or LP concentrations in breast milk. The underlying mechanisms remain to be elucidated. |
format | Online Article Text |
id | pubmed-7729768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77297682020-12-13 Is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters? Nazeri, Pantea Tahmasebinejad, Zhale Hedayati, Mehdi Mirmiran, Parvin Azizi, Fereidoun Matern Child Nutr Original Articles Iodine, a key constituent of thyroid hormones, plays an indirect role in prenatal and postnatal growth. This study aimed to investigate whether breast milk iodine concentration (BMIC) is associated with growth‐ and obesity‐related hormones and subsequently the infants' anthropometric measures. In present study conducted in Tehran (Iran), 94 lactating mothers and healthy infants who were exclusively breastfed were included. Concentrations of iodine, insulin‐like growth factor‐1 (IGF‐1), adiponectin (AD) and leptin (LP) were measured in breast milk samples collected during 3‐ to 5‐day postpartum. Anthropometric measures of infants were assessed at 6 months of life, and age‐ and sex‐specific z‐score values were calculated using the World Health Organization growth standards. The median (interquartile range) iodine, IGF‐1, AD and LP concentrations were 232.5 (157.5–296.0) μg L(−1), 15.7 (11.9–21.1) ng ml(−1), 13.2 (5.1–29.8) mg L(−1) and 1.16 (0.86–1.70) ng ml(−1) in breast milk, respectively. No significant correlations were found between BMIC and IGF‐1, AD and LP concentrations during the first few days postpartum. In adjusted regression model, BMIC was positively associated with weight‐for‐length z score of infants. In the presence of IGF‐1, AD or LP, the coefficients of BMIC for weight‐for‐length z score of infants were β = .003 (P = .021), β = .002 (P = .028) or β = .003 (P = .013), respectively. No other anthropometric measurements were associated with iodine or growth‐ and obesity‐related hormones in breast milk. Our findings indicate that BMIC is a potential contributor to infants' growth status, independent of IGF‐1, AD or LP concentrations in breast milk. The underlying mechanisms remain to be elucidated. John Wiley and Sons Inc. 2020-09-29 /pmc/articles/PMC7729768/ /pubmed/32990418 http://dx.doi.org/10.1111/mcn.13078 Text en © 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Nazeri, Pantea Tahmasebinejad, Zhale Hedayati, Mehdi Mirmiran, Parvin Azizi, Fereidoun Is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters? |
title | Is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters? |
title_full | Is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters? |
title_fullStr | Is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters? |
title_full_unstemmed | Is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters? |
title_short | Is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters? |
title_sort | is breast milk iodine concentration an influential factor in growth‐ and obesity‐related hormones and infants' growth parameters? |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729768/ https://www.ncbi.nlm.nih.gov/pubmed/32990418 http://dx.doi.org/10.1111/mcn.13078 |
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