Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones

A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hy...

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Detalles Bibliográficos
Autores principales: Fadeev, Alexander A., Chagarovskiy, Alexey O., Makarov, Anton S., Levina, Irina I., Ivanova, Olga A., Uchuskin, Maxim G., Trushkov, Igor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729819/
https://www.ncbi.nlm.nih.gov/pubmed/33291488
http://dx.doi.org/10.3390/molecules25235748
Descripción
Sumario:A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds.

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