Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones

A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hy...

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Autores principales: Fadeev, Alexander A., Chagarovskiy, Alexey O., Makarov, Anton S., Levina, Irina I., Ivanova, Olga A., Uchuskin, Maxim G., Trushkov, Igor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729819/
https://www.ncbi.nlm.nih.gov/pubmed/33291488
http://dx.doi.org/10.3390/molecules25235748
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author Fadeev, Alexander A.
Chagarovskiy, Alexey O.
Makarov, Anton S.
Levina, Irina I.
Ivanova, Olga A.
Uchuskin, Maxim G.
Trushkov, Igor V.
author_facet Fadeev, Alexander A.
Chagarovskiy, Alexey O.
Makarov, Anton S.
Levina, Irina I.
Ivanova, Olga A.
Uchuskin, Maxim G.
Trushkov, Igor V.
author_sort Fadeev, Alexander A.
collection PubMed
description A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds.
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spelling pubmed-77298192020-12-12 Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones Fadeev, Alexander A. Chagarovskiy, Alexey O. Makarov, Anton S. Levina, Irina I. Ivanova, Olga A. Uchuskin, Maxim G. Trushkov, Igor V. Molecules Communication A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds. MDPI 2020-12-05 /pmc/articles/PMC7729819/ /pubmed/33291488 http://dx.doi.org/10.3390/molecules25235748 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Fadeev, Alexander A.
Chagarovskiy, Alexey O.
Makarov, Anton S.
Levina, Irina I.
Ivanova, Olga A.
Uchuskin, Maxim G.
Trushkov, Igor V.
Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones
title Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones
title_full Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones
title_fullStr Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones
title_full_unstemmed Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones
title_short Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones
title_sort synthesis of (het)aryl 2-(2-hydroxyaryl)cyclopropyl ketones
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729819/
https://www.ncbi.nlm.nih.gov/pubmed/33291488
http://dx.doi.org/10.3390/molecules25235748
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