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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells

Amplification and/or overexpression of human epidermal growth factor receptor 2 (HER2) are observed in 15–20% of breast cancers (HER2+ breast cancers), and anti-HER2 therapies have significantly improved prognosis of patients with HER2+ breast cancer. One resistance mechanism to anti-HER2 therapies...

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Detalles Bibliográficos
Autores principales:	Fujimoto, Yumi, Morita, Tomoko Yamamori, Ohashi, Akihiro, Haeno, Hiroshi, Hakozaki, Yumi, Fujii, Masanori, Kashima, Yukie, Kobayashi, Susumu S., Mukohara, Toru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729878/ https://www.ncbi.nlm.nih.gov/pubmed/33303839 http://dx.doi.org/10.1038/s41598-020-78646-y

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