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Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence

Irreparable double-strand breaks (DSBs) in response to ionizing radiation (IR) trigger prolonged DNA damage response (DDR) and induce premature senescence. Profound chromatin reorganization with formation of senescence-associated heterochromatin foci (SAHF) is an essential epigenetic mechanism for c...

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Detalles Bibliográficos
Autores principales:	Isermann, Anna, Mann, Carl, Rübe, Claudia E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729917/ https://www.ncbi.nlm.nih.gov/pubmed/33266246 http://dx.doi.org/10.3390/ijms21239130

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