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E3 Ubiquitin Ligase APC/C(Cdh1) Regulation of Phenylalanine Hydroxylase Stability and Function

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by the dysfunction of the enzyme phenylalanine hydroxylase (PAH). Alterations in the level of PAH leads to the toxic accumulation of phenylalanine in the blood and brain. Protein degradation mediated by ubiquitination is a pri...

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Detalles Bibliográficos
Autores principales:	Tyagi, Apoorvi, Sarodaya, Neha, Kaushal, Kamini, Chandrasekaran, Arun Pandian, Antao, Ainsley Mike, Suresh, Bharathi, Rhie, Byung Ho, Kim, Kye Seong, Ramakrishna, Suresh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729981/ https://www.ncbi.nlm.nih.gov/pubmed/33260674 http://dx.doi.org/10.3390/ijms21239076

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