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Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat

The micronutrients iron (Fe) and zinc (Zn) are not only essential for plant survival and proliferation but are crucial for human health. Increasing Fe and Zn levels in edible parts of plants, known as biofortification, is seen a sustainable approach to alleviate micronutrient deficiency in humans. W...

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Autores principales: Tong, Jingyang, Sun, Mengjing, Wang, Yue, Zhang, Yong, Rasheed, Awais, Li, Ming, Xia, Xianchun, He, Zhonghu, Hao, Yuanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730113/
https://www.ncbi.nlm.nih.gov/pubmed/33291360
http://dx.doi.org/10.3390/ijms21239280
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author Tong, Jingyang
Sun, Mengjing
Wang, Yue
Zhang, Yong
Rasheed, Awais
Li, Ming
Xia, Xianchun
He, Zhonghu
Hao, Yuanfeng
author_facet Tong, Jingyang
Sun, Mengjing
Wang, Yue
Zhang, Yong
Rasheed, Awais
Li, Ming
Xia, Xianchun
He, Zhonghu
Hao, Yuanfeng
author_sort Tong, Jingyang
collection PubMed
description The micronutrients iron (Fe) and zinc (Zn) are not only essential for plant survival and proliferation but are crucial for human health. Increasing Fe and Zn levels in edible parts of plants, known as biofortification, is seen a sustainable approach to alleviate micronutrient deficiency in humans. Wheat, as one of the leading staple foods worldwide, is recognized as a prioritized choice for Fe and Zn biofortification. However, to date, limited molecular and physiological mechanisms have been elucidated for Fe and Zn homeostasis in wheat. The expanding molecular understanding of Fe and Zn homeostasis in model plants is providing invaluable resources to biofortify wheat. Recent advancements in NGS (next generation sequencing) technologies coupled with improved wheat genome assembly and high-throughput genotyping platforms have initiated a revolution in resources and approaches for wheat genetic investigations and breeding. Here, we summarize molecular processes and genes involved in Fe and Zn homeostasis in the model plants Arabidopsis and rice, identify their orthologs in the wheat genome, and relate them to known wheat Fe/Zn QTL (quantitative trait locus/loci) based on physical positions. The current study provides the first inventory of the genes regulating grain Fe and Zn homeostasis in wheat, which will benefit gene discovery and breeding, and thereby accelerate the release of Fe- and Zn-enriched wheats.
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spelling pubmed-77301132020-12-12 Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat Tong, Jingyang Sun, Mengjing Wang, Yue Zhang, Yong Rasheed, Awais Li, Ming Xia, Xianchun He, Zhonghu Hao, Yuanfeng Int J Mol Sci Review The micronutrients iron (Fe) and zinc (Zn) are not only essential for plant survival and proliferation but are crucial for human health. Increasing Fe and Zn levels in edible parts of plants, known as biofortification, is seen a sustainable approach to alleviate micronutrient deficiency in humans. Wheat, as one of the leading staple foods worldwide, is recognized as a prioritized choice for Fe and Zn biofortification. However, to date, limited molecular and physiological mechanisms have been elucidated for Fe and Zn homeostasis in wheat. The expanding molecular understanding of Fe and Zn homeostasis in model plants is providing invaluable resources to biofortify wheat. Recent advancements in NGS (next generation sequencing) technologies coupled with improved wheat genome assembly and high-throughput genotyping platforms have initiated a revolution in resources and approaches for wheat genetic investigations and breeding. Here, we summarize molecular processes and genes involved in Fe and Zn homeostasis in the model plants Arabidopsis and rice, identify their orthologs in the wheat genome, and relate them to known wheat Fe/Zn QTL (quantitative trait locus/loci) based on physical positions. The current study provides the first inventory of the genes regulating grain Fe and Zn homeostasis in wheat, which will benefit gene discovery and breeding, and thereby accelerate the release of Fe- and Zn-enriched wheats. MDPI 2020-12-05 /pmc/articles/PMC7730113/ /pubmed/33291360 http://dx.doi.org/10.3390/ijms21239280 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tong, Jingyang
Sun, Mengjing
Wang, Yue
Zhang, Yong
Rasheed, Awais
Li, Ming
Xia, Xianchun
He, Zhonghu
Hao, Yuanfeng
Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat
title Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat
title_full Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat
title_fullStr Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat
title_full_unstemmed Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat
title_short Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat
title_sort dissection of molecular processes and genetic architecture underlying iron and zinc homeostasis for biofortification: from model plants to common wheat
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730113/
https://www.ncbi.nlm.nih.gov/pubmed/33291360
http://dx.doi.org/10.3390/ijms21239280
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