Cargando…

Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer

Background: Oncology patients experience a large number of symptoms and, those referring to cognitive performance has an ever-increasing importance in clinical practice, due to the increase in survival rates and interest in the patient’s quality of life. The studies reviewed showed that chemotherapy...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodríguez Martín, Blanca, Fernández Rodríguez, Eduardo José, Rihuete Galve, María Isabel, Cruz Hernández, Juan Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730121/
https://www.ncbi.nlm.nih.gov/pubmed/33265966
http://dx.doi.org/10.3390/ijerph17238896
_version_ 1783621611439521792
author Rodríguez Martín, Blanca
Fernández Rodríguez, Eduardo José
Rihuete Galve, María Isabel
Cruz Hernández, Juan Jesús
author_facet Rodríguez Martín, Blanca
Fernández Rodríguez, Eduardo José
Rihuete Galve, María Isabel
Cruz Hernández, Juan Jesús
author_sort Rodríguez Martín, Blanca
collection PubMed
description Background: Oncology patients experience a large number of symptoms and, those referring to cognitive performance has an ever-increasing importance in clinical practice, due to the increase in survival rates and interest in the patient’s quality of life. The studies reviewed showed that chemotherapy-related cognitive impairment might occur in 15 and 50% of oncology patients. The main objective of this research was to study the impact of chemotherapy on the cognitive function of patients with locoregional breast cancer. Method: Analytical, prospective, longitudinal study using three measures, unifactorial intrasubject design, non-probability, and random selection sampling. The sample comprised women newly diagnosed with locoregional breast cancer in stages I, II, IIIA who received chemotherapy at the University Hospital of Salamanca (Complejo Asistencial Universitario de Salamanca), randomly selected for three years. Semi-structured interviews were conducted, and anxiety and depression (Hospital Anxiety and Depression scale, HAD); quality of life (QLQ-BR23 scale) and the following cognitive variables were assessed—processing speed, attention, memory, and executive functions (subtests of the Wechsler Intelligence Scale and the Trail Making Test). Results: The final sample size included 151 participants; 23 were excluded. A decline in cognitive performance was observed in patients, which did not completely recover two months after chemotherapy was completed. Additionally, worse cognitive performance was observed in patients with anxious or depressive symptoms. There was a negative impact on the quality of life. Conclusion: Chemotherapy had an impact on the cognitive performance of oncology patients in most cognitive domains studied.
format Online
Article
Text
id pubmed-7730121
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77301212020-12-12 Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer Rodríguez Martín, Blanca Fernández Rodríguez, Eduardo José Rihuete Galve, María Isabel Cruz Hernández, Juan Jesús Int J Environ Res Public Health Article Background: Oncology patients experience a large number of symptoms and, those referring to cognitive performance has an ever-increasing importance in clinical practice, due to the increase in survival rates and interest in the patient’s quality of life. The studies reviewed showed that chemotherapy-related cognitive impairment might occur in 15 and 50% of oncology patients. The main objective of this research was to study the impact of chemotherapy on the cognitive function of patients with locoregional breast cancer. Method: Analytical, prospective, longitudinal study using three measures, unifactorial intrasubject design, non-probability, and random selection sampling. The sample comprised women newly diagnosed with locoregional breast cancer in stages I, II, IIIA who received chemotherapy at the University Hospital of Salamanca (Complejo Asistencial Universitario de Salamanca), randomly selected for three years. Semi-structured interviews were conducted, and anxiety and depression (Hospital Anxiety and Depression scale, HAD); quality of life (QLQ-BR23 scale) and the following cognitive variables were assessed—processing speed, attention, memory, and executive functions (subtests of the Wechsler Intelligence Scale and the Trail Making Test). Results: The final sample size included 151 participants; 23 were excluded. A decline in cognitive performance was observed in patients, which did not completely recover two months after chemotherapy was completed. Additionally, worse cognitive performance was observed in patients with anxious or depressive symptoms. There was a negative impact on the quality of life. Conclusion: Chemotherapy had an impact on the cognitive performance of oncology patients in most cognitive domains studied. MDPI 2020-11-30 2020-12 /pmc/articles/PMC7730121/ /pubmed/33265966 http://dx.doi.org/10.3390/ijerph17238896 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodríguez Martín, Blanca
Fernández Rodríguez, Eduardo José
Rihuete Galve, María Isabel
Cruz Hernández, Juan Jesús
Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer
title Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer
title_full Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer
title_fullStr Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer
title_full_unstemmed Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer
title_short Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer
title_sort study of chemotherapy-induced cognitive impairment in women with breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730121/
https://www.ncbi.nlm.nih.gov/pubmed/33265966
http://dx.doi.org/10.3390/ijerph17238896
work_keys_str_mv AT rodriguezmartinblanca studyofchemotherapyinducedcognitiveimpairmentinwomenwithbreastcancer
AT fernandezrodriguezeduardojose studyofchemotherapyinducedcognitiveimpairmentinwomenwithbreastcancer
AT rihuetegalvemariaisabel studyofchemotherapyinducedcognitiveimpairmentinwomenwithbreastcancer
AT cruzhernandezjuanjesus studyofchemotherapyinducedcognitiveimpairmentinwomenwithbreastcancer