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Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
Skin is the largest human organ and is continuously exposed to various exogenous and endogenous trigger factors affecting body homeostasis. A number of mechanisms, including genetic, inflammatory and autoimmune ones, have been implicated in the pathogenesis of cutaneous diseases. Recently, there has...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730213/ https://www.ncbi.nlm.nih.gov/pubmed/33291683 http://dx.doi.org/10.3390/ijms21239264 |
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author | Khan, Abdul Q. Akhtar, Sabah Prabhu, Kirti S. Zarif, Lubna Khan, Rehan Alam, Majid Buddenkotte, Joerg Ahmad, Aamir Steinhoff, Martin Uddin, Shahab |
author_facet | Khan, Abdul Q. Akhtar, Sabah Prabhu, Kirti S. Zarif, Lubna Khan, Rehan Alam, Majid Buddenkotte, Joerg Ahmad, Aamir Steinhoff, Martin Uddin, Shahab |
author_sort | Khan, Abdul Q. |
collection | PubMed |
description | Skin is the largest human organ and is continuously exposed to various exogenous and endogenous trigger factors affecting body homeostasis. A number of mechanisms, including genetic, inflammatory and autoimmune ones, have been implicated in the pathogenesis of cutaneous diseases. Recently, there has been considerable interest in the role that extracellular vesicles, particularly exosomes, play in human diseases, through their modulation of multiple signaling pathways. Exosomes are nano-sized vesicles secreted by all cell types. They function as cargo carriers shuttling proteins, nucleic acids, lipids etc., thus impacting the cell-cell communications and transfer of vital information/moieties critical for skin homeostasis and disease pathogenesis. This review summarizes the available knowledge on how exosomes affect pathogenesis of cutaneous diseases, and highlights their potential as future targets for the therapy of various skin diseases. |
format | Online Article Text |
id | pubmed-7730213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77302132020-12-12 Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases Khan, Abdul Q. Akhtar, Sabah Prabhu, Kirti S. Zarif, Lubna Khan, Rehan Alam, Majid Buddenkotte, Joerg Ahmad, Aamir Steinhoff, Martin Uddin, Shahab Int J Mol Sci Review Skin is the largest human organ and is continuously exposed to various exogenous and endogenous trigger factors affecting body homeostasis. A number of mechanisms, including genetic, inflammatory and autoimmune ones, have been implicated in the pathogenesis of cutaneous diseases. Recently, there has been considerable interest in the role that extracellular vesicles, particularly exosomes, play in human diseases, through their modulation of multiple signaling pathways. Exosomes are nano-sized vesicles secreted by all cell types. They function as cargo carriers shuttling proteins, nucleic acids, lipids etc., thus impacting the cell-cell communications and transfer of vital information/moieties critical for skin homeostasis and disease pathogenesis. This review summarizes the available knowledge on how exosomes affect pathogenesis of cutaneous diseases, and highlights their potential as future targets for the therapy of various skin diseases. MDPI 2020-12-04 /pmc/articles/PMC7730213/ /pubmed/33291683 http://dx.doi.org/10.3390/ijms21239264 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khan, Abdul Q. Akhtar, Sabah Prabhu, Kirti S. Zarif, Lubna Khan, Rehan Alam, Majid Buddenkotte, Joerg Ahmad, Aamir Steinhoff, Martin Uddin, Shahab Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases |
title | Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases |
title_full | Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases |
title_fullStr | Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases |
title_full_unstemmed | Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases |
title_short | Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases |
title_sort | exosomes: emerging diagnostic and therapeutic targets in cutaneous diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730213/ https://www.ncbi.nlm.nih.gov/pubmed/33291683 http://dx.doi.org/10.3390/ijms21239264 |
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