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Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases

Skin is the largest human organ and is continuously exposed to various exogenous and endogenous trigger factors affecting body homeostasis. A number of mechanisms, including genetic, inflammatory and autoimmune ones, have been implicated in the pathogenesis of cutaneous diseases. Recently, there has...

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Autores principales: Khan, Abdul Q., Akhtar, Sabah, Prabhu, Kirti S., Zarif, Lubna, Khan, Rehan, Alam, Majid, Buddenkotte, Joerg, Ahmad, Aamir, Steinhoff, Martin, Uddin, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730213/
https://www.ncbi.nlm.nih.gov/pubmed/33291683
http://dx.doi.org/10.3390/ijms21239264
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author Khan, Abdul Q.
Akhtar, Sabah
Prabhu, Kirti S.
Zarif, Lubna
Khan, Rehan
Alam, Majid
Buddenkotte, Joerg
Ahmad, Aamir
Steinhoff, Martin
Uddin, Shahab
author_facet Khan, Abdul Q.
Akhtar, Sabah
Prabhu, Kirti S.
Zarif, Lubna
Khan, Rehan
Alam, Majid
Buddenkotte, Joerg
Ahmad, Aamir
Steinhoff, Martin
Uddin, Shahab
author_sort Khan, Abdul Q.
collection PubMed
description Skin is the largest human organ and is continuously exposed to various exogenous and endogenous trigger factors affecting body homeostasis. A number of mechanisms, including genetic, inflammatory and autoimmune ones, have been implicated in the pathogenesis of cutaneous diseases. Recently, there has been considerable interest in the role that extracellular vesicles, particularly exosomes, play in human diseases, through their modulation of multiple signaling pathways. Exosomes are nano-sized vesicles secreted by all cell types. They function as cargo carriers shuttling proteins, nucleic acids, lipids etc., thus impacting the cell-cell communications and transfer of vital information/moieties critical for skin homeostasis and disease pathogenesis. This review summarizes the available knowledge on how exosomes affect pathogenesis of cutaneous diseases, and highlights their potential as future targets for the therapy of various skin diseases.
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spelling pubmed-77302132020-12-12 Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases Khan, Abdul Q. Akhtar, Sabah Prabhu, Kirti S. Zarif, Lubna Khan, Rehan Alam, Majid Buddenkotte, Joerg Ahmad, Aamir Steinhoff, Martin Uddin, Shahab Int J Mol Sci Review Skin is the largest human organ and is continuously exposed to various exogenous and endogenous trigger factors affecting body homeostasis. A number of mechanisms, including genetic, inflammatory and autoimmune ones, have been implicated in the pathogenesis of cutaneous diseases. Recently, there has been considerable interest in the role that extracellular vesicles, particularly exosomes, play in human diseases, through their modulation of multiple signaling pathways. Exosomes are nano-sized vesicles secreted by all cell types. They function as cargo carriers shuttling proteins, nucleic acids, lipids etc., thus impacting the cell-cell communications and transfer of vital information/moieties critical for skin homeostasis and disease pathogenesis. This review summarizes the available knowledge on how exosomes affect pathogenesis of cutaneous diseases, and highlights their potential as future targets for the therapy of various skin diseases. MDPI 2020-12-04 /pmc/articles/PMC7730213/ /pubmed/33291683 http://dx.doi.org/10.3390/ijms21239264 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khan, Abdul Q.
Akhtar, Sabah
Prabhu, Kirti S.
Zarif, Lubna
Khan, Rehan
Alam, Majid
Buddenkotte, Joerg
Ahmad, Aamir
Steinhoff, Martin
Uddin, Shahab
Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
title Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
title_full Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
title_fullStr Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
title_full_unstemmed Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
title_short Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
title_sort exosomes: emerging diagnostic and therapeutic targets in cutaneous diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730213/
https://www.ncbi.nlm.nih.gov/pubmed/33291683
http://dx.doi.org/10.3390/ijms21239264
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