Cargando…

Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage

Transgenic modification of the two most common genes (APPsw, PS1ΔE9) related to familial Alzheimer’s disease (AD) in rats has produced a rodent model that develops pathognomonic signs of AD without genetic tau-protein modification. We used 17-month-old AD rats (n = 8) and age-matched controls (AC, n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kreuzer, Matthias, Keating, Glenda L., Fenzl, Thomas, Härtner, Lorenz, Sinon, Christopher G., Hajjar, Ihab, Ciavatta, Vincent, Rye, David B., García, Paul S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730237/ https://www.ncbi.nlm.nih.gov/pubmed/33291462 http://dx.doi.org/10.3390/ijms21239290

Ejemplares similares

Alterations in theta-gamma coupling and sharp wave-ripple, signs of prodromal hippocampal network impairment in the TgF344-AD rat model
por: van den Berg, Monica, et al.
Publicado: (2023)

Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
por: Chaney, Aisling M, et al.
Publicado: (2021)

Behavioral Phenotype in the TgF344-AD Rat Model of Alzheimer’s Disease
por: Saré, Rachel Michelle, et al.
Publicado: (2020)

Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease
por: Ratner, Marcia H., et al.
Publicado: (2021)

Neurochemical and cognitive changes precede structural abnormalities in the TgF344-AD rat model
por: Fowler, Caitlin F., et al.
Publicado: (2022)

Dentate Granule Cells Are Hyperexcitable in the TgF344-AD Rat Model of Alzheimer's Disease
por: Smith, Lindsey A., et al.
Publicado: (2022)

Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer’s disease
por: Muñoz-Moreno, Emma, et al.
Publicado: (2022)

TgF344-AD Rat Model of Alzheimer’s Disease: Spatial Disorientation and Asymmetry in Hemispheric Neurodegeneration
por: Sagalajev, Boriss, et al.
Publicado: (2023)

Early Spatial Memory Impairment in a Double Transgenic Model of Alzheimer’s Disease TgF-344 AD
por: Proskauer Pena, Stephanie L., et al.
Publicado: (2021)

Early classification of Alzheimer's disease phenotype based on hippocampal electrophysiology in the TgF344-AD rat model
por: Moradi, Faraz, et al.
Publicado: (2023)

Sexual dimorphism in the peripheral metabolic homeostasis and behavior in the TgF344‐AD rat model of Alzheimer's disease
por: Srivastava, Hemant, et al.
Publicado: (2023)

Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats
por: Daianu, Madelaine, et al.
Publicado: (2015)

Resting State Networks in the TgF344-AD Rat Model of Alzheimer’s Disease Are Altered From Early Stages
por: Tudela, Raúl, et al.
Publicado: (2019)

Untargeted metabolomics reveal dysregulations in sugar, methionine, and tyrosine pathways in the prodromal state of AD
por: Hajjar, Ihab, et al.
Publicado: (2020)

Hippocampal but Not Serum Cytokine Levels Are Altered by Traffic-Related Air Pollution in TgF344-AD and Wildtype Fischer 344 Rats in a Sex- and Age-Dependent Manner
por: Patten, Kelley T., et al.
Publicado: (2022)

Neurophysiological signals as predictive translational biomarkers for Alzheimer’s disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats
por: Stoiljkovic, Milan, et al.
Publicado: (2018)

Effects of Magnesium Orotate, Benfotiamine and a Combination of Vitamins on Mitochondrial and Cholinergic Function in the TgF344-AD Rat Model of Alzheimer’s Disease
por: Viel, Christian, et al.
Publicado: (2021)

Measurement of Protein Synthesis Rate in Rat by [(11)C]Leucine PET Imaging: Application to the TgF344-AD Model of Alzheimer’s Disease
por: Bochicchio, D., et al.
Publicado: (2022)

Distinct Parameters in the EEG of the PLP α-SYN Mouse Model for Multiple System Atrophy Reinforce Face Validity
por: Härtner, Lorenz, et al.
Publicado: (2017)

Impairments in Fear Extinction Memory and Basolateral Amygdala Plasticity in the TgF344-AD Rat Model of Alzheimer’s Disease Are Distinct from Nonpathological Aging
por: Hernandez, Caesar M., et al.
Publicado: (2022)

Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats
por: Ceyzériat, Kelly, et al.
Publicado: (2022)

Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer’s disease: three key timepoints through middle-age in females
por: Bernaud, Victoria E., et al.
Publicado: (2022)

Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats
por: van den Berg, Monica, et al.
Publicado: (2022)

Discriminating rapid eye movement sleep from wakefulness by analyzing high frequencies from single-channel EEG recordings in mice
por: Rahimi, Sadegh, et al.
Publicado: (2023)

Progressive impairment of directional and spatially precise trajectories by TgF344-Alzheimer’s disease rats in the Morris Water Task
por: Berkowitz, Laura E., et al.
Publicado: (2018)

FDG PET metabolic signatures distinguishing prodromal DLB and prodromal AD
por: Kantarci, Kejal, et al.
Publicado: (2021)

Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer’s rats
por: Chaudry, Osama, et al.
Publicado: (2022)

Predicting AD Conversion: Comparison between Prodromal AD Guidelines and Computer Assisted PredictAD Tool
por: Liu, Yawu, et al.
Publicado: (2013)

Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer’s disease
por: Hajjar, Ihab, et al.
Publicado: (2022)

Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
por: Moretti, Davide Vito
Publicado: (2015)

Use of mild cognitive impairment and prodromal AD/MCI due to AD in clinical care: a European survey
por: Bertens, Daniela, et al.
Publicado: (2019)

Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition
por: Pellegrini, Carolina, et al.
Publicado: (2020)

A modified Cued Recall Test for detecting prodromal AD in adults with Down syndrome
por: Krinsky‐McHale, Sharon J., et al.
Publicado: (2022)

Anti-Amyloid Therapy, AD, and ARIA: Untangling the Role of CAA
por: Sin, Mo-Kyung, et al.
Publicado: (2023)

Characterization of aEEG During Sleep and Wakefulness in Healthy Children
por: Löffelhardt, Verena T., et al.
Publicado: (2022)

Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease
por: Mitrano, Darlene A., et al.
Publicado: (2021)

Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease
por: Guimarães, Pedro, et al.
Publicado: (2022)

Exploring the Sensitivity of Prodromal Dementia with Lewy Bodies Research Criteria
por: Phillips, Joseph R., et al.
Publicado: (2022)

EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report
por: Carrarini, Claudia, et al.
Publicado: (2022)

Role of TG2 and TGF-β(1) in the pathogenesis of human breast cancer
por: Gao, Hai-Cheng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0bp451c35cmjbjfu5idip8vt8q