Dual mTOR/DNA-PK Inhibitor CC-115 Induces Cell Death in Melanoma Cells and Has Radiosensitizing Potential

CC-115 is a dual inhibitor of the mechanistic target of rapamycin (mTOR) kinase and the DNA-dependent protein kinase (DNA-PK) that is currently being studied in phase I/II clinical trials. DNA-PK is essential for the repair of DNA-double strand breaks (DSB). Radiotherapy is frequently used in the pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Bürkel, Felix, Jost, Tina, Hecht, Markus, Heinzerling, Lucie, Fietkau, Rainer, Distel, Luitpold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730287/
https://www.ncbi.nlm.nih.gov/pubmed/33297429
http://dx.doi.org/10.3390/ijms21239321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730287/
https://www.ncbi.nlm.nih.gov/pubmed/33297429
http://dx.doi.org/10.3390/ijms21239321

Ejemplares similares