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Dual mTOR/DNA-PK Inhibitor CC-115 Induces Cell Death in Melanoma Cells and Has Radiosensitizing Potential

CC-115 is a dual inhibitor of the mechanistic target of rapamycin (mTOR) kinase and the DNA-dependent protein kinase (DNA-PK) that is currently being studied in phase I/II clinical trials. DNA-PK is essential for the repair of DNA-double strand breaks (DSB). Radiotherapy is frequently used in the pa...

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Detalles Bibliográficos
Autores principales:	Bürkel, Felix, Jost, Tina, Hecht, Markus, Heinzerling, Lucie, Fietkau, Rainer, Distel, Luitpold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730287/ https://www.ncbi.nlm.nih.gov/pubmed/33297429 http://dx.doi.org/10.3390/ijms21239321

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