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Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice

Origanum majorana L. is a plant commonly used in folk medicine to treat depression and several neurological disorders. This study aims to evaluate the antidepressant-like effect of the Origanum majorana L. polyphenols (OMP) obtained from the aerial parts using two different depression model tests: T...

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Autores principales: Amaghnouje, Amal, Mechchate, Hamza, Es-safi, Imane, Boukhira, Smahane, S. Aliqahtani, Ali, M. Noman, Omar, A. Nasr, Fahd, Conte, Raffaele, Calarco, Anna, Bousta, Dalila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730305/
https://www.ncbi.nlm.nih.gov/pubmed/33266220
http://dx.doi.org/10.3390/molecules25235653
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author Amaghnouje, Amal
Mechchate, Hamza
Es-safi, Imane
Boukhira, Smahane
S. Aliqahtani, Ali
M. Noman, Omar
A. Nasr, Fahd
Conte, Raffaele
Calarco, Anna
Bousta, Dalila
author_facet Amaghnouje, Amal
Mechchate, Hamza
Es-safi, Imane
Boukhira, Smahane
S. Aliqahtani, Ali
M. Noman, Omar
A. Nasr, Fahd
Conte, Raffaele
Calarco, Anna
Bousta, Dalila
author_sort Amaghnouje, Amal
collection PubMed
description Origanum majorana L. is a plant commonly used in folk medicine to treat depression and several neurological disorders. This study aims to evaluate the antidepressant-like effect of the Origanum majorana L. polyphenols (OMP) obtained from the aerial parts using two different depression model tests: The forced swimming test (FST) and the tail suspension test (TST) in Swiss albino mice. The experiments were performed on days 1, 7, 14, and 21 with daily administration of different treatments. Two different doses were chosen for this study (50 and 100 mg/kg), and paroxetine was used as a positive control. Immobility as a consequence of the depression state was significantly reduced following the treatment with OMP, indicating an antidepressant effect. A subacute toxicity study was also performed following the Organization for Economic Co-operation and Development (OECD) Guidelines (407), showing no sign of toxicity for the studied doses. The phytochemical screening revealed the presence of 12 components, all belonging to polyphenols: Arbutin, rosmarinic acid, ursolic acid, quercetin-3-O-glucoside, quercetin-7-O-glucuronic acid, luteolin-7-O-glucoside, kaempferol-3-0-glucuronic acid, Kaempferol-3-0-pentose, caffeic acid, catechin, quercetin, and rutin. These findings suggest that O. majorana has interesting antidepressant-like properties, which deserve further investigation.
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spelling pubmed-77303052020-12-12 Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice Amaghnouje, Amal Mechchate, Hamza Es-safi, Imane Boukhira, Smahane S. Aliqahtani, Ali M. Noman, Omar A. Nasr, Fahd Conte, Raffaele Calarco, Anna Bousta, Dalila Molecules Article Origanum majorana L. is a plant commonly used in folk medicine to treat depression and several neurological disorders. This study aims to evaluate the antidepressant-like effect of the Origanum majorana L. polyphenols (OMP) obtained from the aerial parts using two different depression model tests: The forced swimming test (FST) and the tail suspension test (TST) in Swiss albino mice. The experiments were performed on days 1, 7, 14, and 21 with daily administration of different treatments. Two different doses were chosen for this study (50 and 100 mg/kg), and paroxetine was used as a positive control. Immobility as a consequence of the depression state was significantly reduced following the treatment with OMP, indicating an antidepressant effect. A subacute toxicity study was also performed following the Organization for Economic Co-operation and Development (OECD) Guidelines (407), showing no sign of toxicity for the studied doses. The phytochemical screening revealed the presence of 12 components, all belonging to polyphenols: Arbutin, rosmarinic acid, ursolic acid, quercetin-3-O-glucoside, quercetin-7-O-glucuronic acid, luteolin-7-O-glucoside, kaempferol-3-0-glucuronic acid, Kaempferol-3-0-pentose, caffeic acid, catechin, quercetin, and rutin. These findings suggest that O. majorana has interesting antidepressant-like properties, which deserve further investigation. MDPI 2020-11-30 /pmc/articles/PMC7730305/ /pubmed/33266220 http://dx.doi.org/10.3390/molecules25235653 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Amaghnouje, Amal
Mechchate, Hamza
Es-safi, Imane
Boukhira, Smahane
S. Aliqahtani, Ali
M. Noman, Omar
A. Nasr, Fahd
Conte, Raffaele
Calarco, Anna
Bousta, Dalila
Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice
title Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice
title_full Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice
title_fullStr Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice
title_full_unstemmed Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice
title_short Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice
title_sort subacute assessment of the toxicity and antidepressant-like effects of origanum majorana l. polyphenols in swiss albino mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730305/
https://www.ncbi.nlm.nih.gov/pubmed/33266220
http://dx.doi.org/10.3390/molecules25235653
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