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Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury

The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney...

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Autores principales: Diniz, Lúcio Ricardo Leite, Souza, Marilia Trindade de Santana, Duarte, Allana Brunna Sucupira, de Sousa, Damião Pergentino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730372/
https://www.ncbi.nlm.nih.gov/pubmed/33297540
http://dx.doi.org/10.3390/molecules25235772
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author Diniz, Lúcio Ricardo Leite
Souza, Marilia Trindade de Santana
Duarte, Allana Brunna Sucupira
de Sousa, Damião Pergentino
author_facet Diniz, Lúcio Ricardo Leite
Souza, Marilia Trindade de Santana
Duarte, Allana Brunna Sucupira
de Sousa, Damião Pergentino
author_sort Diniz, Lúcio Ricardo Leite
collection PubMed
description The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients.
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spelling pubmed-77303722020-12-12 Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury Diniz, Lúcio Ricardo Leite Souza, Marilia Trindade de Santana Duarte, Allana Brunna Sucupira de Sousa, Damião Pergentino Molecules Review The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients. MDPI 2020-12-07 /pmc/articles/PMC7730372/ /pubmed/33297540 http://dx.doi.org/10.3390/molecules25235772 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diniz, Lúcio Ricardo Leite
Souza, Marilia Trindade de Santana
Duarte, Allana Brunna Sucupira
de Sousa, Damião Pergentino
Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury
title Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury
title_full Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury
title_fullStr Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury
title_full_unstemmed Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury
title_short Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury
title_sort mechanistic aspects and therapeutic potential of quercetin against covid-19-associated acute kidney injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730372/
https://www.ncbi.nlm.nih.gov/pubmed/33297540
http://dx.doi.org/10.3390/molecules25235772
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