Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways

Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF. ManN inhibits glycosylation...

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Detalles Bibliográficos
Autores principales: Zhong, Cuiling, Li, Pin, Argade, Sulabha, Liu, Lixian, Chilla’, Anastasia, Liang, Wei, Xin, Hong, Eliceiri, Brian, Choudhury, Biswa, Ferrara, Napoleone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730427/
https://www.ncbi.nlm.nih.gov/pubmed/33303737
http://dx.doi.org/10.1038/s41467-020-20108-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730427/
https://www.ncbi.nlm.nih.gov/pubmed/33303737
http://dx.doi.org/10.1038/s41467-020-20108-0

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