Cargando…

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

Detalles Bibliográficos
Autores principales:	Spetea, Mariana, Schmidhammer, Helmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Editorial
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730540/ https://www.ncbi.nlm.nih.gov/pubmed/33271753 http://dx.doi.org/10.3390/molecules25235658

Ejemplares similares

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II
por: Van Rijn, Richard M., et al.
Publicado: (2022)

Comparison of physicochemical properties and biological activities of opioid morphinans interacting with mu opioid receptors
por: Asim, Muhammad F, et al.
Publicado: (2008)

A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids
por: Asim, Muhammad Faheem, et al.
Publicado: (2010)

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
por: Puls, Kristina, et al.
Publicado: (2022)

Development of Diphenethylamines as Selective Kappa Opioid Receptor Ligands and Their Pharmacological Activities
por: Schmidhammer, Helmut, et al.
Publicado: (2020)

μ Opioid receptor: novel antagonists and structural modeling
por: Kaserer, Teresa, et al.
Publicado: (2016)

Synthesis, opioid receptor binding profile and SAR studies of 14-alkoxy-substituted indolo- and benzofuromorphinans
por: Staaf, Alexander, et al.
Publicado: (2008)

Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile
por: Schmidhammer, Helmut, et al.
Publicado: (2012)

Identification of novel ligands interacting with kappa opioid receptors
por: Spetea, Mariana, et al.
Publicado: (2011)

5-Benzyl substituted 14-methoxymetopon, a high affinity μ opioid receptor agonist with potent antinociceptive activity in mice
por: Spetea, Mariana, et al.
Publicado: (2008)

Discovery and biological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist
por: Spetea, Mariana, et al.
Publicado: (2012)

Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists
por: Noha, Stefan M., et al.
Publicado: (2017)

Development of novel N-methyl and N-allyl-substituted oxazolomorphinans and their interaction with opioid receptors
por: Sipos, Attila, et al.
Publicado: (2011)

In vitro and in vivo Pharmacological Activities of 14-O-Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice
por: Lattanzi, Roberta, et al.
Publicado: (2018)

Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity
por: Ben Haddou, Tanila, et al.
Publicado: (2014)

Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure–Activity Relationships
por: Erli, Filippo, et al.
Publicado: (2017)

Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists
por: Dumitrascuta, Maria, et al.
Publicado: (2017)

N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists
por: Dumitrascuta, Maria, et al.
Publicado: (2020)

Synthesis and Pharmacological Activities of 6-Glycine Substituted 14-Phenylpropoxymorphinans, a Novel Class of Opioids with High Opioid Receptor Affinities and Antinociceptive Potencies
por: Spetea, Mariana, et al.
Publicado: (2011)

In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel μ opioid analgesic with reduced propensity to alter motor function
por: Spetea, Mariana, et al.
Publicado: (2010)

Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor
por: Ben Haddou, Tanila, et al.
Publicado: (2014)

On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance
por: Fürst, Susanna, et al.
Publicado: (2020)

Unveiling 7-Hydroxymitragynine as the Key Active Metabolite of Mitragynine and the Promise for Creating Novel Pain Relievers
por: Spetea, Mariana, et al.
Publicado: (2019)

Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones
por: Spetea, Mariana, et al.
Publicado: (2021)

Opioid Analgesia and Opioid-Induced Adverse Effects: A Review
por: Paul, Alok K., et al.
Publicado: (2021)

Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies
por: Bartuzi, Damian, et al.
Publicado: (2020)

Emerging concepts in drug discovery for cancer therapy
por: Murga, Matilde, et al.
Publicado: (2022)

Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors
por: Meqbil, Yazan J., et al.
Publicado: (2022)

Opioids, opioids, opioids: The plague among middle-aged white Americans
por: Hellman, Matilda
Publicado: (2018)

Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs
por: Lešnik, Samo, et al.
Publicado: (2021)

Prescribing opioids and psychotropic drugs in pregnancy
por: Patrick, Stephen W, et al.
Publicado: (2017)

In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist
por: Puls, Kristina, et al.
Publicado: (2022)

Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14-O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives
por: Spetea, Mariana, et al.
Publicado: (2018)

Editorial: Optimizing opioid prescriptions in the emergency department
por: Dahaba, Ashraf A., et al.
Publicado: (2023)

No Zero Sum in Opioids for Chronic Pain: Neurostimulation and the Goal of Opioid Sparing, Not Opioid Eradication
por: Schatman, Michael E, et al.
Publicado: (2021)

Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery
por: Lee, Yeon Sun
Publicado: (2022)

An Emerging Role for the Delta Opioid Receptor in the Regulation of Mu Opioid Receptor Function
por: Rozenfeld, Raphael, et al.
Publicado: (2007)

Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt(1)]DALDA, and KGOP01, Binding to the Mu Opioid Receptor
por: Dumitrascuta, Maria, et al.
Publicado: (2020)

Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain
por: Schmidhammer, Helmut, et al.
Publicado: (2023)

Opioids and oral P2Y12 receptor inhibitors: A drug–drug interaction
por: Kubica, Jacek
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_93dirahiqlo8bqk1rsh8un01n9