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Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts

Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ergothioneine. OCT/Ns have also been implicated in the t...

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Autores principales: Selo, Mohammed Ali, Sake, Johannes A., Ehrhardt, Carsten, Salomon, Johanna J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730617/
https://www.ncbi.nlm.nih.gov/pubmed/33271927
http://dx.doi.org/10.3390/ijms21239168
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author Selo, Mohammed Ali
Sake, Johannes A.
Ehrhardt, Carsten
Salomon, Johanna J.
author_facet Selo, Mohammed Ali
Sake, Johannes A.
Ehrhardt, Carsten
Salomon, Johanna J.
author_sort Selo, Mohammed Ali
collection PubMed
description Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ergothioneine. OCT/Ns have also been implicated in the transport of xenobiotics across various biological barriers, for example biguanides and histamine receptor antagonists. In addition, several drugs used in the treatment of respiratory disorders are cations at physiological pH and potential substrates of OCT/Ns. OCT/Ns may also be associated with the development of chronic lung diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD) and, thus, are possible new drug targets. As part of the Special Issue “Physiology, Biochemistry and Pharmacology of Transporters for Organic Cations”, this review provides an overview of recent findings on the (patho)physiological and pharmacological functions of organic cation transporters in the lung.
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spelling pubmed-77306172020-12-12 Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts Selo, Mohammed Ali Sake, Johannes A. Ehrhardt, Carsten Salomon, Johanna J. Int J Mol Sci Review Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ergothioneine. OCT/Ns have also been implicated in the transport of xenobiotics across various biological barriers, for example biguanides and histamine receptor antagonists. In addition, several drugs used in the treatment of respiratory disorders are cations at physiological pH and potential substrates of OCT/Ns. OCT/Ns may also be associated with the development of chronic lung diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD) and, thus, are possible new drug targets. As part of the Special Issue “Physiology, Biochemistry and Pharmacology of Transporters for Organic Cations”, this review provides an overview of recent findings on the (patho)physiological and pharmacological functions of organic cation transporters in the lung. MDPI 2020-12-01 /pmc/articles/PMC7730617/ /pubmed/33271927 http://dx.doi.org/10.3390/ijms21239168 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Selo, Mohammed Ali
Sake, Johannes A.
Ehrhardt, Carsten
Salomon, Johanna J.
Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts
title Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts
title_full Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts
title_fullStr Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts
title_full_unstemmed Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts
title_short Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts
title_sort organic cation transporters in the lung—current and emerging (patho)physiological and pharmacological concepts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730617/
https://www.ncbi.nlm.nih.gov/pubmed/33271927
http://dx.doi.org/10.3390/ijms21239168
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