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Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts
Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ergothioneine. OCT/Ns have also been implicated in the t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730617/ https://www.ncbi.nlm.nih.gov/pubmed/33271927 http://dx.doi.org/10.3390/ijms21239168 |
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author | Selo, Mohammed Ali Sake, Johannes A. Ehrhardt, Carsten Salomon, Johanna J. |
author_facet | Selo, Mohammed Ali Sake, Johannes A. Ehrhardt, Carsten Salomon, Johanna J. |
author_sort | Selo, Mohammed Ali |
collection | PubMed |
description | Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ergothioneine. OCT/Ns have also been implicated in the transport of xenobiotics across various biological barriers, for example biguanides and histamine receptor antagonists. In addition, several drugs used in the treatment of respiratory disorders are cations at physiological pH and potential substrates of OCT/Ns. OCT/Ns may also be associated with the development of chronic lung diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD) and, thus, are possible new drug targets. As part of the Special Issue “Physiology, Biochemistry and Pharmacology of Transporters for Organic Cations”, this review provides an overview of recent findings on the (patho)physiological and pharmacological functions of organic cation transporters in the lung. |
format | Online Article Text |
id | pubmed-7730617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77306172020-12-12 Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts Selo, Mohammed Ali Sake, Johannes A. Ehrhardt, Carsten Salomon, Johanna J. Int J Mol Sci Review Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ergothioneine. OCT/Ns have also been implicated in the transport of xenobiotics across various biological barriers, for example biguanides and histamine receptor antagonists. In addition, several drugs used in the treatment of respiratory disorders are cations at physiological pH and potential substrates of OCT/Ns. OCT/Ns may also be associated with the development of chronic lung diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD) and, thus, are possible new drug targets. As part of the Special Issue “Physiology, Biochemistry and Pharmacology of Transporters for Organic Cations”, this review provides an overview of recent findings on the (patho)physiological and pharmacological functions of organic cation transporters in the lung. MDPI 2020-12-01 /pmc/articles/PMC7730617/ /pubmed/33271927 http://dx.doi.org/10.3390/ijms21239168 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Selo, Mohammed Ali Sake, Johannes A. Ehrhardt, Carsten Salomon, Johanna J. Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts |
title | Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts |
title_full | Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts |
title_fullStr | Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts |
title_full_unstemmed | Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts |
title_short | Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts |
title_sort | organic cation transporters in the lung—current and emerging (patho)physiological and pharmacological concepts |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730617/ https://www.ncbi.nlm.nih.gov/pubmed/33271927 http://dx.doi.org/10.3390/ijms21239168 |
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