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Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730621/ https://www.ncbi.nlm.nih.gov/pubmed/33256207 http://dx.doi.org/10.3390/molecules25235557 |
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author | Ghiulai, Roxana Roşca, Oana Janina Antal, Diana Simona Mioc, Marius Mioc, Alexandra Racoviceanu, Roxana Macaşoi, Ioana Olariu, Tudor Dehelean, Cristina Creţu, Octavian Marius Voicu, Mirela Şoica, Codruţa |
author_facet | Ghiulai, Roxana Roşca, Oana Janina Antal, Diana Simona Mioc, Marius Mioc, Alexandra Racoviceanu, Roxana Macaşoi, Ioana Olariu, Tudor Dehelean, Cristina Creţu, Octavian Marius Voicu, Mirela Şoica, Codruţa |
author_sort | Ghiulai, Roxana |
collection | PubMed |
description | Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments. |
format | Online Article Text |
id | pubmed-7730621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77306212020-12-12 Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches Ghiulai, Roxana Roşca, Oana Janina Antal, Diana Simona Mioc, Marius Mioc, Alexandra Racoviceanu, Roxana Macaşoi, Ioana Olariu, Tudor Dehelean, Cristina Creţu, Octavian Marius Voicu, Mirela Şoica, Codruţa Molecules Review Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments. MDPI 2020-11-26 /pmc/articles/PMC7730621/ /pubmed/33256207 http://dx.doi.org/10.3390/molecules25235557 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ghiulai, Roxana Roşca, Oana Janina Antal, Diana Simona Mioc, Marius Mioc, Alexandra Racoviceanu, Roxana Macaşoi, Ioana Olariu, Tudor Dehelean, Cristina Creţu, Octavian Marius Voicu, Mirela Şoica, Codruţa Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches |
title | Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches |
title_full | Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches |
title_fullStr | Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches |
title_full_unstemmed | Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches |
title_short | Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches |
title_sort | tetracyclic and pentacyclic triterpenes with high therapeutic efficiency in wound healing approaches |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730621/ https://www.ncbi.nlm.nih.gov/pubmed/33256207 http://dx.doi.org/10.3390/molecules25235557 |
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