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Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since...

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Autores principales: Ghiulai, Roxana, Roşca, Oana Janina, Antal, Diana Simona, Mioc, Marius, Mioc, Alexandra, Racoviceanu, Roxana, Macaşoi, Ioana, Olariu, Tudor, Dehelean, Cristina, Creţu, Octavian Marius, Voicu, Mirela, Şoica, Codruţa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730621/
https://www.ncbi.nlm.nih.gov/pubmed/33256207
http://dx.doi.org/10.3390/molecules25235557
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author Ghiulai, Roxana
Roşca, Oana Janina
Antal, Diana Simona
Mioc, Marius
Mioc, Alexandra
Racoviceanu, Roxana
Macaşoi, Ioana
Olariu, Tudor
Dehelean, Cristina
Creţu, Octavian Marius
Voicu, Mirela
Şoica, Codruţa
author_facet Ghiulai, Roxana
Roşca, Oana Janina
Antal, Diana Simona
Mioc, Marius
Mioc, Alexandra
Racoviceanu, Roxana
Macaşoi, Ioana
Olariu, Tudor
Dehelean, Cristina
Creţu, Octavian Marius
Voicu, Mirela
Şoica, Codruţa
author_sort Ghiulai, Roxana
collection PubMed
description Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.
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spelling pubmed-77306212020-12-12 Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches Ghiulai, Roxana Roşca, Oana Janina Antal, Diana Simona Mioc, Marius Mioc, Alexandra Racoviceanu, Roxana Macaşoi, Ioana Olariu, Tudor Dehelean, Cristina Creţu, Octavian Marius Voicu, Mirela Şoica, Codruţa Molecules Review Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments. MDPI 2020-11-26 /pmc/articles/PMC7730621/ /pubmed/33256207 http://dx.doi.org/10.3390/molecules25235557 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghiulai, Roxana
Roşca, Oana Janina
Antal, Diana Simona
Mioc, Marius
Mioc, Alexandra
Racoviceanu, Roxana
Macaşoi, Ioana
Olariu, Tudor
Dehelean, Cristina
Creţu, Octavian Marius
Voicu, Mirela
Şoica, Codruţa
Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
title Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
title_full Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
title_fullStr Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
title_full_unstemmed Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
title_short Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
title_sort tetracyclic and pentacyclic triterpenes with high therapeutic efficiency in wound healing approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730621/
https://www.ncbi.nlm.nih.gov/pubmed/33256207
http://dx.doi.org/10.3390/molecules25235557
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