Pharmacological Inhibition of CDK8 in Triple-Negative Breast Cancer Cell Line MDA-MB-468 Increases E2F1 Protein, Induces Phosphorylation of STAT3 and Apoptosis

Cyclin-dependent kinase 8 (CDK8) has been identified as a colon cancer oncogene. Since this initial observation, CDK8 has been implicated as a potential driver of other cancers including acute myelogenous leukemia (AML) and some breast cancers. Here, we observed different biological responses to CDK...

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Detalles Bibliográficos
Autores principales: Spear, Jensen M., Lu, Zhixin, Russu, Wade A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730658/
https://www.ncbi.nlm.nih.gov/pubmed/33291686
http://dx.doi.org/10.3390/molecules25235728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730658/
https://www.ncbi.nlm.nih.gov/pubmed/33291686
http://dx.doi.org/10.3390/molecules25235728

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