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Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery

In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used drug carrier, and the only NP system currently approved by the FDA for clinical use, owing to their advantageous physicochemical properties and excellent biocompatibility. Recent advances in liposome technology have been...

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Detalles Bibliográficos
Autores principales: Almeida, Bethany, Nag, Okhil K., Rogers, Katherine E., Delehanty, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730700/
https://www.ncbi.nlm.nih.gov/pubmed/33271886
http://dx.doi.org/10.3390/molecules25235672
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author Almeida, Bethany
Nag, Okhil K.
Rogers, Katherine E.
Delehanty, James B.
author_facet Almeida, Bethany
Nag, Okhil K.
Rogers, Katherine E.
Delehanty, James B.
author_sort Almeida, Bethany
collection PubMed
description In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used drug carrier, and the only NP system currently approved by the FDA for clinical use, owing to their advantageous physicochemical properties and excellent biocompatibility. Recent advances in liposome technology have been focused on bioconjugation strategies to improve drug loading, targeting, and overall efficacy. In this review, we highlight recent literature reports (covering the last five years) focused on bioconjugation strategies for the enhancement of liposome-mediated drug delivery. These advances encompass the improvement of drug loading/incorporation and the specific targeting of liposomes to the site of interest/drug action. We conclude with a section highlighting the role of bioconjugation strategies in liposome systems currently being evaluated for clinical use and a forward-looking discussion of the field of liposomal drug delivery.
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spelling pubmed-77307002020-12-12 Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery Almeida, Bethany Nag, Okhil K. Rogers, Katherine E. Delehanty, James B. Molecules Review In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used drug carrier, and the only NP system currently approved by the FDA for clinical use, owing to their advantageous physicochemical properties and excellent biocompatibility. Recent advances in liposome technology have been focused on bioconjugation strategies to improve drug loading, targeting, and overall efficacy. In this review, we highlight recent literature reports (covering the last five years) focused on bioconjugation strategies for the enhancement of liposome-mediated drug delivery. These advances encompass the improvement of drug loading/incorporation and the specific targeting of liposomes to the site of interest/drug action. We conclude with a section highlighting the role of bioconjugation strategies in liposome systems currently being evaluated for clinical use and a forward-looking discussion of the field of liposomal drug delivery. MDPI 2020-12-01 /pmc/articles/PMC7730700/ /pubmed/33271886 http://dx.doi.org/10.3390/molecules25235672 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Almeida, Bethany
Nag, Okhil K.
Rogers, Katherine E.
Delehanty, James B.
Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
title Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
title_full Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
title_fullStr Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
title_full_unstemmed Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
title_short Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
title_sort recent progress in bioconjugation strategies for liposome-mediated drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730700/
https://www.ncbi.nlm.nih.gov/pubmed/33271886
http://dx.doi.org/10.3390/molecules25235672
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