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Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used drug carrier, and the only NP system currently approved by the FDA for clinical use, owing to their advantageous physicochemical properties and excellent biocompatibility. Recent advances in liposome technology have been...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730700/ https://www.ncbi.nlm.nih.gov/pubmed/33271886 http://dx.doi.org/10.3390/molecules25235672 |
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author | Almeida, Bethany Nag, Okhil K. Rogers, Katherine E. Delehanty, James B. |
author_facet | Almeida, Bethany Nag, Okhil K. Rogers, Katherine E. Delehanty, James B. |
author_sort | Almeida, Bethany |
collection | PubMed |
description | In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used drug carrier, and the only NP system currently approved by the FDA for clinical use, owing to their advantageous physicochemical properties and excellent biocompatibility. Recent advances in liposome technology have been focused on bioconjugation strategies to improve drug loading, targeting, and overall efficacy. In this review, we highlight recent literature reports (covering the last five years) focused on bioconjugation strategies for the enhancement of liposome-mediated drug delivery. These advances encompass the improvement of drug loading/incorporation and the specific targeting of liposomes to the site of interest/drug action. We conclude with a section highlighting the role of bioconjugation strategies in liposome systems currently being evaluated for clinical use and a forward-looking discussion of the field of liposomal drug delivery. |
format | Online Article Text |
id | pubmed-7730700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77307002020-12-12 Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery Almeida, Bethany Nag, Okhil K. Rogers, Katherine E. Delehanty, James B. Molecules Review In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used drug carrier, and the only NP system currently approved by the FDA for clinical use, owing to their advantageous physicochemical properties and excellent biocompatibility. Recent advances in liposome technology have been focused on bioconjugation strategies to improve drug loading, targeting, and overall efficacy. In this review, we highlight recent literature reports (covering the last five years) focused on bioconjugation strategies for the enhancement of liposome-mediated drug delivery. These advances encompass the improvement of drug loading/incorporation and the specific targeting of liposomes to the site of interest/drug action. We conclude with a section highlighting the role of bioconjugation strategies in liposome systems currently being evaluated for clinical use and a forward-looking discussion of the field of liposomal drug delivery. MDPI 2020-12-01 /pmc/articles/PMC7730700/ /pubmed/33271886 http://dx.doi.org/10.3390/molecules25235672 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Almeida, Bethany Nag, Okhil K. Rogers, Katherine E. Delehanty, James B. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery |
title | Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery |
title_full | Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery |
title_fullStr | Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery |
title_full_unstemmed | Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery |
title_short | Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery |
title_sort | recent progress in bioconjugation strategies for liposome-mediated drug delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730700/ https://www.ncbi.nlm.nih.gov/pubmed/33271886 http://dx.doi.org/10.3390/molecules25235672 |
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