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Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge

The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism. In recent years, RdRp has emerged as an optimal target for the development of antiviral drugs, as demonstrated by recent approva...

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Detalles Bibliográficos
Autores principales:	Picarazzi, Francesca, Vicenti, Ilaria, Saladini, Francesco, Zazzi, Maurizio, Mori, Mattia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730706/ https://www.ncbi.nlm.nih.gov/pubmed/33287144 http://dx.doi.org/10.3390/molecules25235695

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