Prostate cancer and therapeutic challenges

Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shoc...

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Autores principales: Hawsawi, Yousef MohammedRabaa, Zailaie, Samar Abdullah, Oyouni, Atif Abdulwahab A., Alzahrani, Othman Rashed, Alamer, Osama Mohamed, Aljohani, Saad Ali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730758/
https://www.ncbi.nlm.nih.gov/pubmed/33303035
http://dx.doi.org/10.1186/s40709-020-00128-z
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author Hawsawi, Yousef MohammedRabaa
Zailaie, Samar Abdullah
Oyouni, Atif Abdulwahab A.
Alzahrani, Othman Rashed
Alamer, Osama Mohamed
Aljohani, Saad Ali S.
author_facet Hawsawi, Yousef MohammedRabaa
Zailaie, Samar Abdullah
Oyouni, Atif Abdulwahab A.
Alzahrani, Othman Rashed
Alamer, Osama Mohamed
Aljohani, Saad Ali S.
author_sort Hawsawi, Yousef MohammedRabaa
collection PubMed
description Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone deprivation and the transition to PC androgen independence is a major health obstacle. In this review, we aim to detail the roles of androgens, androgen receptors and sex steroid hormones in inducing apoptosis in PC.
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spelling pubmed-77307582020-12-11 Prostate cancer and therapeutic challenges Hawsawi, Yousef MohammedRabaa Zailaie, Samar Abdullah Oyouni, Atif Abdulwahab A. Alzahrani, Othman Rashed Alamer, Osama Mohamed Aljohani, Saad Ali S. J Biol Res (Thessalon) Review Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone deprivation and the transition to PC androgen independence is a major health obstacle. In this review, we aim to detail the roles of androgens, androgen receptors and sex steroid hormones in inducing apoptosis in PC. BioMed Central 2020-12-10 /pmc/articles/PMC7730758/ /pubmed/33303035 http://dx.doi.org/10.1186/s40709-020-00128-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Hawsawi, Yousef MohammedRabaa
Zailaie, Samar Abdullah
Oyouni, Atif Abdulwahab A.
Alzahrani, Othman Rashed
Alamer, Osama Mohamed
Aljohani, Saad Ali S.
Prostate cancer and therapeutic challenges
title Prostate cancer and therapeutic challenges
title_full Prostate cancer and therapeutic challenges
title_fullStr Prostate cancer and therapeutic challenges
title_full_unstemmed Prostate cancer and therapeutic challenges
title_short Prostate cancer and therapeutic challenges
title_sort prostate cancer and therapeutic challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730758/
https://www.ncbi.nlm.nih.gov/pubmed/33303035
http://dx.doi.org/10.1186/s40709-020-00128-z
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