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Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology
Bergenia (Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug formulation obtained from the rhizomes of B. ligulat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730924/ https://www.ncbi.nlm.nih.gov/pubmed/33256153 http://dx.doi.org/10.3390/molecules25235555 |
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author | Koul, Bhupendra Kumar, Arvind Yadav, Dhananjay Jin, Jun-O. |
author_facet | Koul, Bhupendra Kumar, Arvind Yadav, Dhananjay Jin, Jun-O. |
author_sort | Koul, Bhupendra |
collection | PubMed |
description | Bergenia (Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug formulation obtained from the rhizomes of B. ligulata. Bergenia species also possess several other biological activities like diuretic, antidiabetic, antitussive, insecticidal, anti-inflammatory, antipyretic, anti-bradykinin, antiviral, antibacterial, antimalarial, hepatoprotective, antiulcer, anticancer, antioxidant, antiobesity, and adaptogenic. This review provides explicit information on the traditional uses, phytochemistry, and pharmacological significance of the genus Bergenia. The extant literature concerned was systematically collected from various databases, weblinks, blogs, books, and theses to select 174 references for detailed analysis. To date, 152 chemical constituents have been identified and characterized from the genus Bergenia that belong to the chemical classes of polyphenols, phenolic-glycosides, lactones, quinones, sterols, tannins, terpenes, and others. B. crassifolia alone possesses 104 bioactive compounds. Meticulous pharmacological and phytochemical studies on Bergenia species and its conservation could yield more reliable compounds and products of pharmacological significance for better healthcare. |
format | Online Article Text |
id | pubmed-7730924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77309242020-12-12 Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology Koul, Bhupendra Kumar, Arvind Yadav, Dhananjay Jin, Jun-O. Molecules Review Bergenia (Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug formulation obtained from the rhizomes of B. ligulata. Bergenia species also possess several other biological activities like diuretic, antidiabetic, antitussive, insecticidal, anti-inflammatory, antipyretic, anti-bradykinin, antiviral, antibacterial, antimalarial, hepatoprotective, antiulcer, anticancer, antioxidant, antiobesity, and adaptogenic. This review provides explicit information on the traditional uses, phytochemistry, and pharmacological significance of the genus Bergenia. The extant literature concerned was systematically collected from various databases, weblinks, blogs, books, and theses to select 174 references for detailed analysis. To date, 152 chemical constituents have been identified and characterized from the genus Bergenia that belong to the chemical classes of polyphenols, phenolic-glycosides, lactones, quinones, sterols, tannins, terpenes, and others. B. crassifolia alone possesses 104 bioactive compounds. Meticulous pharmacological and phytochemical studies on Bergenia species and its conservation could yield more reliable compounds and products of pharmacological significance for better healthcare. MDPI 2020-11-26 /pmc/articles/PMC7730924/ /pubmed/33256153 http://dx.doi.org/10.3390/molecules25235555 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Koul, Bhupendra Kumar, Arvind Yadav, Dhananjay Jin, Jun-O. Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology |
title | Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_full | Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_fullStr | Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_full_unstemmed | Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_short | Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_sort | bergenia genus: traditional uses, phytochemistry and pharmacology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730924/ https://www.ncbi.nlm.nih.gov/pubmed/33256153 http://dx.doi.org/10.3390/molecules25235555 |
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