Cargando…
pH-Sensitive Biomaterials for Drug Delivery
The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenviron...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730929/ https://www.ncbi.nlm.nih.gov/pubmed/33266162 http://dx.doi.org/10.3390/molecules25235649 |
_version_ | 1783621798213976064 |
---|---|
author | Zhuo, Shijie Zhang, Feng Yu, Junyu Zhang, Xican Yang, Guangbao Liu, Xiaowen |
author_facet | Zhuo, Shijie Zhang, Feng Yu, Junyu Zhang, Xican Yang, Guangbao Liu, Xiaowen |
author_sort | Zhuo, Shijie |
collection | PubMed |
description | The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials. |
format | Online Article Text |
id | pubmed-7730929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77309292020-12-12 pH-Sensitive Biomaterials for Drug Delivery Zhuo, Shijie Zhang, Feng Yu, Junyu Zhang, Xican Yang, Guangbao Liu, Xiaowen Molecules Review The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials. MDPI 2020-11-30 /pmc/articles/PMC7730929/ /pubmed/33266162 http://dx.doi.org/10.3390/molecules25235649 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhuo, Shijie Zhang, Feng Yu, Junyu Zhang, Xican Yang, Guangbao Liu, Xiaowen pH-Sensitive Biomaterials for Drug Delivery |
title | pH-Sensitive Biomaterials for Drug Delivery |
title_full | pH-Sensitive Biomaterials for Drug Delivery |
title_fullStr | pH-Sensitive Biomaterials for Drug Delivery |
title_full_unstemmed | pH-Sensitive Biomaterials for Drug Delivery |
title_short | pH-Sensitive Biomaterials for Drug Delivery |
title_sort | ph-sensitive biomaterials for drug delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730929/ https://www.ncbi.nlm.nih.gov/pubmed/33266162 http://dx.doi.org/10.3390/molecules25235649 |
work_keys_str_mv | AT zhuoshijie phsensitivebiomaterialsfordrugdelivery AT zhangfeng phsensitivebiomaterialsfordrugdelivery AT yujunyu phsensitivebiomaterialsfordrugdelivery AT zhangxican phsensitivebiomaterialsfordrugdelivery AT yangguangbao phsensitivebiomaterialsfordrugdelivery AT liuxiaowen phsensitivebiomaterialsfordrugdelivery |