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pH-Sensitive Biomaterials for Drug Delivery

The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenviron...

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Detalles Bibliográficos
Autores principales: Zhuo, Shijie, Zhang, Feng, Yu, Junyu, Zhang, Xican, Yang, Guangbao, Liu, Xiaowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730929/
https://www.ncbi.nlm.nih.gov/pubmed/33266162
http://dx.doi.org/10.3390/molecules25235649
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author Zhuo, Shijie
Zhang, Feng
Yu, Junyu
Zhang, Xican
Yang, Guangbao
Liu, Xiaowen
author_facet Zhuo, Shijie
Zhang, Feng
Yu, Junyu
Zhang, Xican
Yang, Guangbao
Liu, Xiaowen
author_sort Zhuo, Shijie
collection PubMed
description The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials.
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spelling pubmed-77309292020-12-12 pH-Sensitive Biomaterials for Drug Delivery Zhuo, Shijie Zhang, Feng Yu, Junyu Zhang, Xican Yang, Guangbao Liu, Xiaowen Molecules Review The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials. MDPI 2020-11-30 /pmc/articles/PMC7730929/ /pubmed/33266162 http://dx.doi.org/10.3390/molecules25235649 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhuo, Shijie
Zhang, Feng
Yu, Junyu
Zhang, Xican
Yang, Guangbao
Liu, Xiaowen
pH-Sensitive Biomaterials for Drug Delivery
title pH-Sensitive Biomaterials for Drug Delivery
title_full pH-Sensitive Biomaterials for Drug Delivery
title_fullStr pH-Sensitive Biomaterials for Drug Delivery
title_full_unstemmed pH-Sensitive Biomaterials for Drug Delivery
title_short pH-Sensitive Biomaterials for Drug Delivery
title_sort ph-sensitive biomaterials for drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730929/
https://www.ncbi.nlm.nih.gov/pubmed/33266162
http://dx.doi.org/10.3390/molecules25235649
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