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The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women
Short-chain fatty acids (SCFAs) mediate the transmission of signals between the microbiome and the immune system and are responsible for maintaining balance in the anti-inflammatory reaction. Pregnancy stages alter the gut microbiota community structure, which also synthesizes SCFAs. The study invol...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731050/ https://www.ncbi.nlm.nih.gov/pubmed/33287163 http://dx.doi.org/10.3390/ijms21239212 |
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author | Szczuko, Małgorzata Kikut, Justyna Maciejewska, Dominika Kulpa, Danuta Celewicz, Zbigniew Ziętek, Maciej |
author_facet | Szczuko, Małgorzata Kikut, Justyna Maciejewska, Dominika Kulpa, Danuta Celewicz, Zbigniew Ziętek, Maciej |
author_sort | Szczuko, Małgorzata |
collection | PubMed |
description | Short-chain fatty acids (SCFAs) mediate the transmission of signals between the microbiome and the immune system and are responsible for maintaining balance in the anti-inflammatory reaction. Pregnancy stages alter the gut microbiota community structure, which also synthesizes SCFAs. The study involved 90 pregnant women, divided into two groups: 48 overweight/obese pregnant women (OW) and 42 pregnant women with normal BMI (CG). The blood samples for glucose, insulin, and HBA1c were analyzed as well as stool samples for SCFA isolation (C2:0; C3:0; C4:0i; C4:0n; C5:0i; C5:0n; C6:0i; C6:0n) using gas chromatography. The SCFA profile in the analyzed groups differed significantly. A significant positive correlation between C2:0, C3:0, C4:0n and anthropometric measurements, and between C2:0, C3:0, C4:0n, and C5:0n and parameters of carbohydrate metabolism was found. SCFA levels fluctuate during pregnancy and the course of pregnancy and participate in the change in carbohydrate metabolism as well. The influence of C2:0 during pregnancy on anthropometric parameters was visible in both groups (normal weight and obese). Butyrate and propionate regulate glucose metabolism by stimulating the process of intestinal gluconeogenesis. The level of propionic acid decreases with the course of pregnancy, while its increase is characteristic of obese women, which is associated with many metabolic adaptations. Propionic and linear caproic acid levels can be an important critical point in maintaining lower anthropometric parameters during pregnancy. |
format | Online Article Text |
id | pubmed-7731050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77310502020-12-12 The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women Szczuko, Małgorzata Kikut, Justyna Maciejewska, Dominika Kulpa, Danuta Celewicz, Zbigniew Ziętek, Maciej Int J Mol Sci Article Short-chain fatty acids (SCFAs) mediate the transmission of signals between the microbiome and the immune system and are responsible for maintaining balance in the anti-inflammatory reaction. Pregnancy stages alter the gut microbiota community structure, which also synthesizes SCFAs. The study involved 90 pregnant women, divided into two groups: 48 overweight/obese pregnant women (OW) and 42 pregnant women with normal BMI (CG). The blood samples for glucose, insulin, and HBA1c were analyzed as well as stool samples for SCFA isolation (C2:0; C3:0; C4:0i; C4:0n; C5:0i; C5:0n; C6:0i; C6:0n) using gas chromatography. The SCFA profile in the analyzed groups differed significantly. A significant positive correlation between C2:0, C3:0, C4:0n and anthropometric measurements, and between C2:0, C3:0, C4:0n, and C5:0n and parameters of carbohydrate metabolism was found. SCFA levels fluctuate during pregnancy and the course of pregnancy and participate in the change in carbohydrate metabolism as well. The influence of C2:0 during pregnancy on anthropometric parameters was visible in both groups (normal weight and obese). Butyrate and propionate regulate glucose metabolism by stimulating the process of intestinal gluconeogenesis. The level of propionic acid decreases with the course of pregnancy, while its increase is characteristic of obese women, which is associated with many metabolic adaptations. Propionic and linear caproic acid levels can be an important critical point in maintaining lower anthropometric parameters during pregnancy. MDPI 2020-12-03 /pmc/articles/PMC7731050/ /pubmed/33287163 http://dx.doi.org/10.3390/ijms21239212 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Szczuko, Małgorzata Kikut, Justyna Maciejewska, Dominika Kulpa, Danuta Celewicz, Zbigniew Ziętek, Maciej The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women |
title | The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women |
title_full | The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women |
title_fullStr | The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women |
title_full_unstemmed | The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women |
title_short | The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women |
title_sort | associations of scfa with anthropometric parameters and carbohydrate metabolism in pregnant women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731050/ https://www.ncbi.nlm.nih.gov/pubmed/33287163 http://dx.doi.org/10.3390/ijms21239212 |
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