Cargando…

The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women

Short-chain fatty acids (SCFAs) mediate the transmission of signals between the microbiome and the immune system and are responsible for maintaining balance in the anti-inflammatory reaction. Pregnancy stages alter the gut microbiota community structure, which also synthesizes SCFAs. The study invol...

Descripción completa

Detalles Bibliográficos
Autores principales: Szczuko, Małgorzata, Kikut, Justyna, Maciejewska, Dominika, Kulpa, Danuta, Celewicz, Zbigniew, Ziętek, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731050/
https://www.ncbi.nlm.nih.gov/pubmed/33287163
http://dx.doi.org/10.3390/ijms21239212
_version_ 1783621826297987072
author Szczuko, Małgorzata
Kikut, Justyna
Maciejewska, Dominika
Kulpa, Danuta
Celewicz, Zbigniew
Ziętek, Maciej
author_facet Szczuko, Małgorzata
Kikut, Justyna
Maciejewska, Dominika
Kulpa, Danuta
Celewicz, Zbigniew
Ziętek, Maciej
author_sort Szczuko, Małgorzata
collection PubMed
description Short-chain fatty acids (SCFAs) mediate the transmission of signals between the microbiome and the immune system and are responsible for maintaining balance in the anti-inflammatory reaction. Pregnancy stages alter the gut microbiota community structure, which also synthesizes SCFAs. The study involved 90 pregnant women, divided into two groups: 48 overweight/obese pregnant women (OW) and 42 pregnant women with normal BMI (CG). The blood samples for glucose, insulin, and HBA1c were analyzed as well as stool samples for SCFA isolation (C2:0; C3:0; C4:0i; C4:0n; C5:0i; C5:0n; C6:0i; C6:0n) using gas chromatography. The SCFA profile in the analyzed groups differed significantly. A significant positive correlation between C2:0, C3:0, C4:0n and anthropometric measurements, and between C2:0, C3:0, C4:0n, and C5:0n and parameters of carbohydrate metabolism was found. SCFA levels fluctuate during pregnancy and the course of pregnancy and participate in the change in carbohydrate metabolism as well. The influence of C2:0 during pregnancy on anthropometric parameters was visible in both groups (normal weight and obese). Butyrate and propionate regulate glucose metabolism by stimulating the process of intestinal gluconeogenesis. The level of propionic acid decreases with the course of pregnancy, while its increase is characteristic of obese women, which is associated with many metabolic adaptations. Propionic and linear caproic acid levels can be an important critical point in maintaining lower anthropometric parameters during pregnancy.
format Online
Article
Text
id pubmed-7731050
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77310502020-12-12 The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women Szczuko, Małgorzata Kikut, Justyna Maciejewska, Dominika Kulpa, Danuta Celewicz, Zbigniew Ziętek, Maciej Int J Mol Sci Article Short-chain fatty acids (SCFAs) mediate the transmission of signals between the microbiome and the immune system and are responsible for maintaining balance in the anti-inflammatory reaction. Pregnancy stages alter the gut microbiota community structure, which also synthesizes SCFAs. The study involved 90 pregnant women, divided into two groups: 48 overweight/obese pregnant women (OW) and 42 pregnant women with normal BMI (CG). The blood samples for glucose, insulin, and HBA1c were analyzed as well as stool samples for SCFA isolation (C2:0; C3:0; C4:0i; C4:0n; C5:0i; C5:0n; C6:0i; C6:0n) using gas chromatography. The SCFA profile in the analyzed groups differed significantly. A significant positive correlation between C2:0, C3:0, C4:0n and anthropometric measurements, and between C2:0, C3:0, C4:0n, and C5:0n and parameters of carbohydrate metabolism was found. SCFA levels fluctuate during pregnancy and the course of pregnancy and participate in the change in carbohydrate metabolism as well. The influence of C2:0 during pregnancy on anthropometric parameters was visible in both groups (normal weight and obese). Butyrate and propionate regulate glucose metabolism by stimulating the process of intestinal gluconeogenesis. The level of propionic acid decreases with the course of pregnancy, while its increase is characteristic of obese women, which is associated with many metabolic adaptations. Propionic and linear caproic acid levels can be an important critical point in maintaining lower anthropometric parameters during pregnancy. MDPI 2020-12-03 /pmc/articles/PMC7731050/ /pubmed/33287163 http://dx.doi.org/10.3390/ijms21239212 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szczuko, Małgorzata
Kikut, Justyna
Maciejewska, Dominika
Kulpa, Danuta
Celewicz, Zbigniew
Ziętek, Maciej
The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women
title The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women
title_full The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women
title_fullStr The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women
title_full_unstemmed The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women
title_short The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women
title_sort associations of scfa with anthropometric parameters and carbohydrate metabolism in pregnant women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731050/
https://www.ncbi.nlm.nih.gov/pubmed/33287163
http://dx.doi.org/10.3390/ijms21239212
work_keys_str_mv AT szczukomałgorzata theassociationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT kikutjustyna theassociationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT maciejewskadominika theassociationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT kulpadanuta theassociationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT celewiczzbigniew theassociationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT zietekmaciej theassociationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT szczukomałgorzata associationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT kikutjustyna associationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT maciejewskadominika associationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT kulpadanuta associationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT celewiczzbigniew associationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen
AT zietekmaciej associationsofscfawithanthropometricparametersandcarbohydratemetabolisminpregnantwomen