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The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients
Background. The rapid onset of a systemic pro-inflammatory state followed by acute respiratory distress syndrome is the leading cause of mortality in patients with COVID-19. We performed a retrospective observational study to explore the capacity of different complete blood cell count (CBC)-derived...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731255/ https://www.ncbi.nlm.nih.gov/pubmed/33291581 http://dx.doi.org/10.3390/molecules25235725 |
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author | Fois, Alessandro G. Paliogiannis, Panagiotis Scano, Valentina Cau, Stefania Babudieri, Sergio Perra, Roberto Ruzzittu, Giulia Zinellu, Elisabetta Pirina, Pietro Carru, Ciriaco Arru, Luigi B. Fancellu, Alessandro Mondoni, Michele Mangoni, Arduino A. Zinellu, Angelo |
author_facet | Fois, Alessandro G. Paliogiannis, Panagiotis Scano, Valentina Cau, Stefania Babudieri, Sergio Perra, Roberto Ruzzittu, Giulia Zinellu, Elisabetta Pirina, Pietro Carru, Ciriaco Arru, Luigi B. Fancellu, Alessandro Mondoni, Michele Mangoni, Arduino A. Zinellu, Angelo |
author_sort | Fois, Alessandro G. |
collection | PubMed |
description | Background. The rapid onset of a systemic pro-inflammatory state followed by acute respiratory distress syndrome is the leading cause of mortality in patients with COVID-19. We performed a retrospective observational study to explore the capacity of different complete blood cell count (CBC)-derived inflammation indexes to predict in-hospital mortality in this group. Methods. The neutrophil to lymphocyte ratio (NLR), derived NLR (dNLR), platelet to lymphocyte ratio (PLR), mean platelet volume to platelet ratio (MPR), neutrophil to lymphocyte × platelet ratio (NLPR), monocyte to lymphocyte ratio (MLR), systemic inflammation response index (SIRI), systemic inflammation index (SII), and the aggregate index of systemic inflammation (AISI) were calculated on hospital admission in 119 patients with laboratory confirmed COVID-19. Results. Non-survivors had significantly higher AISI, dNLR, NLPR, NLR, SII, and SIRI values when compared to survivors. Similarly, Kaplan–Meier survival curves showed significantly lower survival in patients with higher AISI, dNLR, MLR, NLPR, NLR, SII, and SIRI. However, after adjusting for confounders, only the SII remained significantly associated with survival (HR = 1.0001; 95% CI, 1.0000–1.0001, p = 0.029) in multivariate Cox regression analysis. Conclusions. The SII on admission independently predicts in-hospital mortality in COVID-19 patients and may assist with early risk stratification in this group. |
format | Online Article Text |
id | pubmed-7731255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77312552020-12-12 The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients Fois, Alessandro G. Paliogiannis, Panagiotis Scano, Valentina Cau, Stefania Babudieri, Sergio Perra, Roberto Ruzzittu, Giulia Zinellu, Elisabetta Pirina, Pietro Carru, Ciriaco Arru, Luigi B. Fancellu, Alessandro Mondoni, Michele Mangoni, Arduino A. Zinellu, Angelo Molecules Article Background. The rapid onset of a systemic pro-inflammatory state followed by acute respiratory distress syndrome is the leading cause of mortality in patients with COVID-19. We performed a retrospective observational study to explore the capacity of different complete blood cell count (CBC)-derived inflammation indexes to predict in-hospital mortality in this group. Methods. The neutrophil to lymphocyte ratio (NLR), derived NLR (dNLR), platelet to lymphocyte ratio (PLR), mean platelet volume to platelet ratio (MPR), neutrophil to lymphocyte × platelet ratio (NLPR), monocyte to lymphocyte ratio (MLR), systemic inflammation response index (SIRI), systemic inflammation index (SII), and the aggregate index of systemic inflammation (AISI) were calculated on hospital admission in 119 patients with laboratory confirmed COVID-19. Results. Non-survivors had significantly higher AISI, dNLR, NLPR, NLR, SII, and SIRI values when compared to survivors. Similarly, Kaplan–Meier survival curves showed significantly lower survival in patients with higher AISI, dNLR, MLR, NLPR, NLR, SII, and SIRI. However, after adjusting for confounders, only the SII remained significantly associated with survival (HR = 1.0001; 95% CI, 1.0000–1.0001, p = 0.029) in multivariate Cox regression analysis. Conclusions. The SII on admission independently predicts in-hospital mortality in COVID-19 patients and may assist with early risk stratification in this group. MDPI 2020-12-04 /pmc/articles/PMC7731255/ /pubmed/33291581 http://dx.doi.org/10.3390/molecules25235725 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fois, Alessandro G. Paliogiannis, Panagiotis Scano, Valentina Cau, Stefania Babudieri, Sergio Perra, Roberto Ruzzittu, Giulia Zinellu, Elisabetta Pirina, Pietro Carru, Ciriaco Arru, Luigi B. Fancellu, Alessandro Mondoni, Michele Mangoni, Arduino A. Zinellu, Angelo The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients |
title | The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients |
title_full | The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients |
title_fullStr | The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients |
title_full_unstemmed | The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients |
title_short | The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients |
title_sort | systemic inflammation index on admission predicts in-hospital mortality in covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731255/ https://www.ncbi.nlm.nih.gov/pubmed/33291581 http://dx.doi.org/10.3390/molecules25235725 |
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