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Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects

The employment studies of natural extracts in the prevention and treatment of several diseases highlighted the role of different species of genus Ferula L., belonging to the Apiaceae family, dicotyledonous plants present in many temperate zones of our planet. Ferula communis L. is the main source of...

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Autores principales: Macrì, Roberta, Musolino, Vincenzo, Gliozzi, Micaela, Carresi, Cristina, Maiuolo, Jessica, Nucera, Saverio, Scicchitano, Miriam, Bosco, Francesca, Scarano, Federica, Ruga, Stefano, Zito, Maria Caterina, Guarnieri, Lorenza, Bombardelli, Ezio, Mollace, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731292/
https://www.ncbi.nlm.nih.gov/pubmed/33297504
http://dx.doi.org/10.3390/molecules25235768
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author Macrì, Roberta
Musolino, Vincenzo
Gliozzi, Micaela
Carresi, Cristina
Maiuolo, Jessica
Nucera, Saverio
Scicchitano, Miriam
Bosco, Francesca
Scarano, Federica
Ruga, Stefano
Zito, Maria Caterina
Guarnieri, Lorenza
Bombardelli, Ezio
Mollace, Vincenzo
author_facet Macrì, Roberta
Musolino, Vincenzo
Gliozzi, Micaela
Carresi, Cristina
Maiuolo, Jessica
Nucera, Saverio
Scicchitano, Miriam
Bosco, Francesca
Scarano, Federica
Ruga, Stefano
Zito, Maria Caterina
Guarnieri, Lorenza
Bombardelli, Ezio
Mollace, Vincenzo
author_sort Macrì, Roberta
collection PubMed
description The employment studies of natural extracts in the prevention and treatment of several diseases highlighted the role of different species of genus Ferula L., belonging to the Apiaceae family, dicotyledonous plants present in many temperate zones of our planet. Ferula communis L. is the main source of sesquiterpene ferutinin, a bioactive compound studied both in vitro and in vivo, because of different effects, such as phytoestrogenic, antioxidant, anti-inflammatory, but also antiproliferative and cytotoxic activity, performed in a dose-dependent and cell-dependent way. The present review will focus on the molecular mechanisms involved in the different activities of Ferutinin, starting from its antioxidant potential at low doses until its ionophoric property and the subsequent mitochondrial dysfunction induced through administration of high doses, which represent the key point of its anticancer action. Furthermore, we will summarize the data acquired from some experimental studies on different cell types and on several diseases. The results obtained showed an important antioxidant and phytoestrogenic regulation with lack of typical side effects related to estrogenic therapy. The preferential cell death induction for tumor cell lines suggests that ferutinin may have anti-neoplastic properties, and may be used as an antiproliferative and cytotoxic agent in an estrogen dependent and independent manner. Nevertheless, more data are needed to clearly understand the effect of ferutinin in animals before using it as a phytoestrogen or anticancer drug.
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spelling pubmed-77312922020-12-12 Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects Macrì, Roberta Musolino, Vincenzo Gliozzi, Micaela Carresi, Cristina Maiuolo, Jessica Nucera, Saverio Scicchitano, Miriam Bosco, Francesca Scarano, Federica Ruga, Stefano Zito, Maria Caterina Guarnieri, Lorenza Bombardelli, Ezio Mollace, Vincenzo Molecules Review The employment studies of natural extracts in the prevention and treatment of several diseases highlighted the role of different species of genus Ferula L., belonging to the Apiaceae family, dicotyledonous plants present in many temperate zones of our planet. Ferula communis L. is the main source of sesquiterpene ferutinin, a bioactive compound studied both in vitro and in vivo, because of different effects, such as phytoestrogenic, antioxidant, anti-inflammatory, but also antiproliferative and cytotoxic activity, performed in a dose-dependent and cell-dependent way. The present review will focus on the molecular mechanisms involved in the different activities of Ferutinin, starting from its antioxidant potential at low doses until its ionophoric property and the subsequent mitochondrial dysfunction induced through administration of high doses, which represent the key point of its anticancer action. Furthermore, we will summarize the data acquired from some experimental studies on different cell types and on several diseases. The results obtained showed an important antioxidant and phytoestrogenic regulation with lack of typical side effects related to estrogenic therapy. The preferential cell death induction for tumor cell lines suggests that ferutinin may have anti-neoplastic properties, and may be used as an antiproliferative and cytotoxic agent in an estrogen dependent and independent manner. Nevertheless, more data are needed to clearly understand the effect of ferutinin in animals before using it as a phytoestrogen or anticancer drug. MDPI 2020-12-07 /pmc/articles/PMC7731292/ /pubmed/33297504 http://dx.doi.org/10.3390/molecules25235768 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Macrì, Roberta
Musolino, Vincenzo
Gliozzi, Micaela
Carresi, Cristina
Maiuolo, Jessica
Nucera, Saverio
Scicchitano, Miriam
Bosco, Francesca
Scarano, Federica
Ruga, Stefano
Zito, Maria Caterina
Guarnieri, Lorenza
Bombardelli, Ezio
Mollace, Vincenzo
Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects
title Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects
title_full Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects
title_fullStr Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects
title_full_unstemmed Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects
title_short Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects
title_sort ferula l. plant extracts and dose-dependent activity of natural sesquiterpene ferutinin: from antioxidant potential to cytotoxic effects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731292/
https://www.ncbi.nlm.nih.gov/pubmed/33297504
http://dx.doi.org/10.3390/molecules25235768
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