Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation Is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104

Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system. Since glutamate and microglia are important in the pathogenesis of epilepsy, we investigated the possible action of the synthetic kynurenic acid analogue, SZR104, in epileptic mice and...

Descripción completa

Detalles Bibliográficos
Autores principales: Lajkó, Noémi, Kata, Diana, Szabó, Melinda, Mátyás, Adrienne, Dulka, Karolina, Földesi, Imre, Fülöp, Ferenc, Gulya, Karoly, Vécsei, László, Mihály, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731372/
https://www.ncbi.nlm.nih.gov/pubmed/33297593
http://dx.doi.org/10.3390/ijms21239333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731372/
https://www.ncbi.nlm.nih.gov/pubmed/33297593
http://dx.doi.org/10.3390/ijms21239333

Ejemplares similares