Cargando…

Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation Is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104

Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system. Since glutamate and microglia are important in the pathogenesis of epilepsy, we investigated the possible action of the synthetic kynurenic acid analogue, SZR104, in epileptic mice and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lajkó, Noémi, Kata, Diana, Szabó, Melinda, Mátyás, Adrienne, Dulka, Karolina, Földesi, Imre, Fülöp, Ferenc, Gulya, Karoly, Vécsei, László, Mihály, András
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731372/ https://www.ncbi.nlm.nih.gov/pubmed/33297593 http://dx.doi.org/10.3390/ijms21239333

Ejemplares similares

The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia
por: Szabo, Melinda, et al.
Publicado: (2023)

Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains
por: Szabo, Melinda, et al.
Publicado: (2022)

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
por: Molnár, Kinga, et al.
Publicado: (2021)

Differential Effects of Hypothermia and SZR72 on Cerebral Kynurenine and Kynurenic Acid in a Piglet Model of Hypoxic–Ischemic Encephalopathy
por: Domoki, Ferenc, et al.
Publicado: (2023)

Quantitative morphometric and cell-type-specific population analysis of microglia-enriched cultures subcloned to high purity from newborn rat brains
por: Dulka, Karolina, et al.
Publicado: (2021)

Divergent Effects of the N-Methyl-D-Aspartate Receptor Antagonist Kynurenic Acid and the Synthetic Analog SZR-72 on Microcirculatory and Mitochondrial Dysfunction in Experimental Sepsis
por: Juhász, László, et al.
Publicado: (2020)

Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis
por: Balla, Zsolt, et al.
Publicado: (2021)

Epigenetic Consequences of in Utero Exposure to Rosuvastatin: Alteration of Histone Methylation Patterns in Newborn Rat Brains
por: Dulka, Karolina, et al.
Publicado: (2021)

The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy
por: Kovács, Viktória, et al.
Publicado: (2021)

Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations
por: Bohár, Zsuzsanna, et al.
Publicado: (2015)

Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs
por: Fehér, Evelin, et al.
Publicado: (2019)

Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers
por: Datki, Zsolt, et al.
Publicado: (2019)

Decreased plasma concentrations of kynurenine and kynurenic acid in schizophrenia patients
por: Markovic, M., et al.
Publicado: (2023)

Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)
por: Lukács, M., et al.
Publicado: (2017)

Kynurenic Acid Inhibits the Electrical Stimulation Induced Elevated Pituitary Adenylate Cyclase-Activating Polypeptide Expression in the TNC
por: Körtési, Tamás, et al.
Publicado: (2018)

The Opposite Effects of Kynurenic Acid and Different Kynurenic Acid Analogs on Tumor Necrosis Factor-α (TNF-α) Production and Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) Expression
por: Mándi, Yvette, et al.
Publicado: (2019)

Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion
por: Csáti, A., et al.
Publicado: (2015)

Orofacial skin inflammation increases the number of macrophages in the maxillary subregion of the rat trigeminal ganglion in a corticosteroid-reversible manner
por: Legradi, Adam, et al.
Publicado: (2020)

The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue
por: Rossi, Franca, et al.
Publicado: (2019)

KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion
por: Lukács, M., et al.
Publicado: (2016)

Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats
por: Poles, Marietta Z., et al.
Publicado: (2021)

Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro
por: Sekine, Airi, et al.
Publicado: (2015)

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives
por: Lőrinczi, Bálint, et al.
Publicado: (2020)

The Metabolic Factor Kynurenic Acid of Kynurenine Pathway Predicts Major Depressive Disorder
por: Liu, Hongye, et al.
Publicado: (2018)

Serum Kynurenic Acid and Kynurenine Are Negatively Associated with the Risk of Adult Moyamoya Disease
por: Yu, Xiaofan, et al.
Publicado: (2022)

Smouldering Lesion in MS: Microglia, Lymphocytes and Pathobiochemical Mechanisms
por: Pukoli, Dániel, et al.
Publicado: (2023)

Tryptophan, Kynurenine and Kynurenic Acid Concentrations in Milk and Serum of Dairy Cows with Prototheca Mastitis
por: Bochniarz, Mariola, et al.
Publicado: (2021)

Activation of the Kynurenine Pathway and Production of Inflammatory Cytokines by Astrocytes and Microglia Infected With Neospora caninum
por: Argolo, Deivison Silva, et al.
Publicado: (2022)

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects
por: Majláth, Zsófia, et al.
Publicado: (2016)

Cluster headache and kynurenines
por: Tuka, Bernadett, et al.
Publicado: (2023)

Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid
por: Joisten, Niklas, et al.
Publicado: (2020)

Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
por: Saran, Tomasz, et al.
Publicado: (2021)

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism
por: Tanaka, Masaru, et al.
Publicado: (2020)

Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection
por: Sas, Katalin, et al.
Publicado: (2018)

Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission
por: Martos, Diána, et al.
Publicado: (2022)

The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women
por: Quan, Chengxuan, et al.
Publicado: (2020)

Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease
por: Orsatti, Laura, et al.
Publicado: (2021)

Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder
por: Yildirim, Veli, et al.
Publicado: (2023)

Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid
por: Tóth, Fanni, et al.
Publicado: (2021)

Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability
por: Oláh, Gáspár, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_nu26h1ijqm1ou965ntsf39s35h