Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function

BACKGROUND: Of the genes that control mitochondrial biogenesis and function, ERRα emerges as a druggable metabolic target to be exploited for cancer therapy. Of the genes mutated in cancer, TP53 remains the most elusive to target. A clear understanding of how mitochondrial druggable targets can be a...

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Detalles Bibliográficos
Autores principales: De Vitto, Humberto, Ryu, Joohyun, Calderon-Aparicio, Ali, Monts, Josh, Dey, Raja, Chakraborty, Abhijit, Lee, Mee-Hyun, Bode, Ann M., Dong, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731476/
https://www.ncbi.nlm.nih.gov/pubmed/33303020
http://dx.doi.org/10.1186/s40170-020-00234-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731476/
https://www.ncbi.nlm.nih.gov/pubmed/33303020
http://dx.doi.org/10.1186/s40170-020-00234-5

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