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Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review
BACKGROUND: Low-grade myofibroblastic sarcoma (LGMS) is described as a distinct atypical myofibroblastic tumor often with fibromatosis-like features and predilection for the head and neck, especially the oral cavity and larynx. LGMS arising in the levator scapulae muscle is extremely rare. CASE PRES...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731512/ https://www.ncbi.nlm.nih.gov/pubmed/33302922 http://dx.doi.org/10.1186/s12891-020-03857-3 |
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author | Yonezawa, Hirotaka Yamamoto, Norio Hayashi, Katsuhiro Takeuchi, Akihiko Miwa, Shinji Igarashi, Kentaro Langit, Mickhael Bang Kimura, Hiroaki Shimozaki, Shingo Kato, Takashi Morinaga, Sei Araki, Yoshihiro Asano, Yohei Ikeda, Hiroko Nojima, Takayuki Tsuchiya, Hiroyuki |
author_facet | Yonezawa, Hirotaka Yamamoto, Norio Hayashi, Katsuhiro Takeuchi, Akihiko Miwa, Shinji Igarashi, Kentaro Langit, Mickhael Bang Kimura, Hiroaki Shimozaki, Shingo Kato, Takashi Morinaga, Sei Araki, Yoshihiro Asano, Yohei Ikeda, Hiroko Nojima, Takayuki Tsuchiya, Hiroyuki |
author_sort | Yonezawa, Hirotaka |
collection | PubMed |
description | BACKGROUND: Low-grade myofibroblastic sarcoma (LGMS) is described as a distinct atypical myofibroblastic tumor often with fibromatosis-like features and predilection for the head and neck, especially the oral cavity and larynx. LGMS arising in the levator scapulae muscle is extremely rare. CASE PRESENTATION: A 69-year-old woman was admitted to our hospital because she noticed a hard mass in her left neck six months prior. Magnetic resonance images (MRI) showed a soft tissue tumor of the left levator scapulae muscle. A core needle biopsy showed cellular fascicles or a storiform growth pattern of spindle-shaped tumor cells with minimally atypia. Immunohistochemistry revealed focally positive for α-smooth muscle actin (α-SMA), negative for S-100, and a low-grade spindle cell sarcoma was suspected. Following a biopsy, the tumor was resected with a wide surgical margin. Immunohistochemical staining was a positive for vimentin and α-SMA and negative for desmin, CD34, nuclear β-catenin, and h-caldesmon. LGMS diagnosis was determined based on the histopathological findings. The patient was alive with no evidence of disease eight years after the surgery. CONCLUSIONS: To the best of our knowledge, this is the first case report of LGMS arising in the levator scapulae muscle. In addition to the case report, 48 reports with 103 LGMS cases are reviewed and discussed. In previous reports of LGMS, there were 43 females and 60 males, with a mean age of 43.0 years (range, 2–75). There were 13 (12.6%) patients aged < 18 years, 67 (65.1%) patients aged 18 to 59 years, and 23 (22.3%) patients aged ≥60 years. The average tumor size was 4.4 cm (range: 0.4–22.0). The commonest sites of LGMS was the tongue. Tumor growth patterns were evaluated in 52 cases, and 44 cases (84.6%) showed infiltrative growth patterns. Local recurrence was 26.7%, and distant metastasis was 4.4%. Because of the locally aggressive feature, it is important to diagnose LGMS with biopsy and to excise the tumor with an adequately wide margin. |
format | Online Article Text |
id | pubmed-7731512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77315122020-12-15 Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review Yonezawa, Hirotaka Yamamoto, Norio Hayashi, Katsuhiro Takeuchi, Akihiko Miwa, Shinji Igarashi, Kentaro Langit, Mickhael Bang Kimura, Hiroaki Shimozaki, Shingo Kato, Takashi Morinaga, Sei Araki, Yoshihiro Asano, Yohei Ikeda, Hiroko Nojima, Takayuki Tsuchiya, Hiroyuki BMC Musculoskelet Disord Case Report BACKGROUND: Low-grade myofibroblastic sarcoma (LGMS) is described as a distinct atypical myofibroblastic tumor often with fibromatosis-like features and predilection for the head and neck, especially the oral cavity and larynx. LGMS arising in the levator scapulae muscle is extremely rare. CASE PRESENTATION: A 69-year-old woman was admitted to our hospital because she noticed a hard mass in her left neck six months prior. Magnetic resonance images (MRI) showed a soft tissue tumor of the left levator scapulae muscle. A core needle biopsy showed cellular fascicles or a storiform growth pattern of spindle-shaped tumor cells with minimally atypia. Immunohistochemistry revealed focally positive for α-smooth muscle actin (α-SMA), negative for S-100, and a low-grade spindle cell sarcoma was suspected. Following a biopsy, the tumor was resected with a wide surgical margin. Immunohistochemical staining was a positive for vimentin and α-SMA and negative for desmin, CD34, nuclear β-catenin, and h-caldesmon. LGMS diagnosis was determined based on the histopathological findings. The patient was alive with no evidence of disease eight years after the surgery. CONCLUSIONS: To the best of our knowledge, this is the first case report of LGMS arising in the levator scapulae muscle. In addition to the case report, 48 reports with 103 LGMS cases are reviewed and discussed. In previous reports of LGMS, there were 43 females and 60 males, with a mean age of 43.0 years (range, 2–75). There were 13 (12.6%) patients aged < 18 years, 67 (65.1%) patients aged 18 to 59 years, and 23 (22.3%) patients aged ≥60 years. The average tumor size was 4.4 cm (range: 0.4–22.0). The commonest sites of LGMS was the tongue. Tumor growth patterns were evaluated in 52 cases, and 44 cases (84.6%) showed infiltrative growth patterns. Local recurrence was 26.7%, and distant metastasis was 4.4%. Because of the locally aggressive feature, it is important to diagnose LGMS with biopsy and to excise the tumor with an adequately wide margin. BioMed Central 2020-12-10 /pmc/articles/PMC7731512/ /pubmed/33302922 http://dx.doi.org/10.1186/s12891-020-03857-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Yonezawa, Hirotaka Yamamoto, Norio Hayashi, Katsuhiro Takeuchi, Akihiko Miwa, Shinji Igarashi, Kentaro Langit, Mickhael Bang Kimura, Hiroaki Shimozaki, Shingo Kato, Takashi Morinaga, Sei Araki, Yoshihiro Asano, Yohei Ikeda, Hiroko Nojima, Takayuki Tsuchiya, Hiroyuki Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review |
title | Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review |
title_full | Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review |
title_fullStr | Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review |
title_full_unstemmed | Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review |
title_short | Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review |
title_sort | low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731512/ https://www.ncbi.nlm.nih.gov/pubmed/33302922 http://dx.doi.org/10.1186/s12891-020-03857-3 |
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